糖皮质激素对T管窦道形成影响的实验研究  

Effcts of glucocorticoid on sinus formation of T-tube

作　　者：王李华[1] 周一农[1] 钱军[1] 陆炜[1] 徐天生[1] 

机构地区：[1]衢州市人民医院普外科,324000

出　　处：《浙江医学》2010年第1期68-70,共3页Zhejiang Medical Journal

基　　金：浙江省医药卫生优秀青年科技人才专项科研基金（2002QN020）

摘　　要：目的探讨糖皮质激素对胆总管切开T管引流狗模型的T管窦道形成的影响。方法制作狗胆总管切开T管引流模型。分为对照组、糖皮质激素短期使用组、糖皮质激素中长期使用组，每组8只。测量胆总管直径、大网膜长度及有无变异、胃和横结肠的蠕动次数。制模2周后再次开腹，检测T管窦道长度和完整性；以窦道的加压注水量作为窦道所能承受的压力指标，分析不同组间的差异以及多种因素对加压注水量的影响。结果3组之间胆总管直径、胃蠕动次数、横结肠蠕动次数、大网膜长度及窦道长度的差异均无统计学意义（P〉0．05）；对照组和糖皮质激素短期使用组的T管窦道形成完整；而糖皮质激素中长期使用组有50％窦道不完整；完整的T管窦道行加压注水，3组间加压注水量的差异有统计学意义（P〈0．01）；而在其它的所有因素中对T管窦道加压注水量影响最大的是大网膜长度，两者呈正相关（P〈0．01）。结论中长期应用糖皮质激素明显阻碍T管窦道的形成，影响窦道的完整性和坚固程度；而短期应用对T管窦道形成的影响较小。Objective To investigate the effects of glucocorticoid on the sinus formation of T-tube in dogs with choledochostomy and T-tube drianage. Methods The dogs with T-tube after choledochostomy were divided into the control group, glucocorticoid short-term treatment group and glucocorticoid mid-long-term treatment group, 8 dogs each group. Choledochus diameter, greater omentum length and variation, and the frequency of stomach and transverse colon peristalsis were determined. T-tube sinus length and integrity were detected after 2 weeks, respectively. The influence of different treatment and other factors on the pressurized affusion volume as the pressure parameter of the T-tube sinus solidity was analyzed. Results Choledochus diameter, greater omentum length, and the frequency of stomach and transverse colon peristalsis are no difference obviously in 3 groups （P〉0.05）. As compared with the control group and glucocortieoid short-term treatment group, 50% T-tube sinus had not formed completely in glucocorticoid mid-long-term treatment group. The pressurized affusion volume was significantly variation among 3 groups （P=0.002）. In other factors, the greater omentum length is the most important factor witch can interfere the pressurized affusion volume and has a positive correlation （P=0.002）. Conclusion The glucocorticoid mid-long-term treatment can obviously interfere T-tube sinus formation and influence its integrity and solidity.

关 键 词：T管 窦道 糖皮质激素 狗 

分 类 号：R562.25[医药卫生—呼吸系统] R711.34[医药卫生—内科学]