产超广谱β-内酰胺酶细菌的耐药性分析  

Resistant analysis for extended-spectrum β-lactamases-producing organisms

作　　者：屈春燕[1] 姜红[1] 

机构地区：[1]四川省成都市第七人民医院,610021

出　　处：《医学信息（中旬刊）》2010年第1期143-144,共2页Medical Information Operations Sciences Fascicule

摘　　要：目的:探讨产ESBLs菌的发生率、耐药特点,为临床治疗提供参考。方法:采用微量肉汤稀释法对139株大肠埃希菌、64株肺炎克雷伯菌和17株产酸克雷伯菌做药敏试验,同时用纸片扩散法确证产ESBLs菌。结果:产ESBLs菌的检出率分别为:大肠埃希菌41.7%(2007年)和46.8%(2008年);肺炎克雷伯菌25%(2007年)和52.3%(2008年);产酸克雷伯菌66.7%(2007年)和50%(2008年),产ESBLs菌耐药率普遍高于非产ESBLs菌(P<0.01或P<0.05)。结论:常规检测和监测产ESBLs菌十分必要,这对指导临床合理用药、有效控制感染的传播意义重大。Objective ： To study the resistant characteristics of ESBLs - producing isolates , and provide references for clinical treatment. Methods ： MIC test was taken by broth microdilution method in 139 strains of Escherichia coli ,64 strains of Klebsiella pneumoniae and 17 strains of Klebsiella oxytoca. ESBLs confirmation test was performed for the doubtful isolates. Results ：25（41.7% ） of the 60 strains in 2007 and 37（46. 8% ） of the 79 strains in 2008 of Escheriehia coli produced ESBLs. 5（25% ） of the 20 strains in 2007 and 23（52.3% ） of the 44strains in 2008 of Klebsiella pneumoniae produced ESBLs. 2（66.7% ） of the 3 strains in 2007 and 7（50% ） of the 14 strains in 2008 of Klebsiella oxytoca produced ESBLs. The levels of resistance in the ESBLs - positive was significantly higher than those in the ESBLs - negative. Conclusions ： It is necessary to examine and monitor ESBLs in normal ,and it is suitable for the treatment and control of infections caused by the ESBLs- positive.

关 键 词：Β-内酰胺酶类 抗药性 微生物 大肠埃希菌 克雷伯菌 肺炎 克雷伯菌 产酸 

分 类 号：R446.5[医药卫生—诊断学] R181.34[医药卫生—临床医学]