整合子基因盒系统及β-内酰胺酶介导的细菌耐药  

The System of Integron-gene Cassettes and β-Lactamase Mediated Antibiotic Resistance

作　　者：国宪虎[1] 夏蕊蕊[1] 徐海[1] 

机构地区：[1]山东大学微生物技术国家重点实验室,山东济南250100

出　　处：《微生物学通报》2010年第2期289-294,共6页Microbiology China

基　　金：国家自然科学基金面上项目(No.30870084);山东大学微生物技术国家重点实验室自主项目

摘　　要：整合子是一个能捕获并整合细胞外游离基因盒,并可使之转化为功能性基因的新型DNA元件。这种可移动的基因元件通过水平基因转移的方式极大地加速了抗性基因在同种及不同种属之间的传播,造成细菌的耐药以至多重耐药问题日益严重,耐药机制日趋复杂。尤其对临床上使用较多的头孢菌素类、青霉素类等β-内酰胺类抗生素的耐药,已给人类健康造成巨大威胁,急需阐明其复杂的耐药机制。Integrons are novel DNA elements, which can capture and incorporate gene cassettes embedded in exogenous by site-specific recombination. Meanwhile, they are able to convent gene cassettes to functional genes by ensuring their correct expression. The horizontal transfer of this genetic element within and between microbial genera has speeded up emergence of novel antibiotic resistance gene. To date, the mechanism of resistance to antibiotics, particularly β-Lactam class of antibiotic, is becoming exceedingly complex. What is more, multi-drug resistant microbes with complex resistance patterns have posed an increasing threat to the health. So intensive research leading to greater understanding is imperative.

关 键 词：整合子 水平基因转移 Β-内酰胺酶 耐药机制 基因盒 

分 类 号：R346[医药卫生—基础医学]