维司力农对培养鸡胚心室肌细胞内向整流性钾电流的作用  

Effect of vesnarinone on inward rectifier potassium current in cultured embryonic ventricular myocytes

作　　者：蔡志伟[1] 蓝庭剑[2] 朱寄天 曾晓荣[4] 

机构地区：[1]汕头大学医学院生理教研室,汕头515031 [2]华西医科大学生理学教研室,成都610041 [3]成都体育大学运动生理学教研室,成都610000 [4]泸州医学院心肌电生理学研究室,泸州646000

出　　处：《中国药理学通报》1998年第5期455-458,共4页Chinese Pharmacological Bulletin

摘　　要：目的研究维司力农对培养鸡胚心室肌细胞内向整流性钾电流（Ik1）的作用。方法采用细胞贴附式膜片钳技术。结果1×10-5mol·L-1维司力农可抑制Ik1通道的稳态电导，同时使斜率电导从28.44pS降至10.77pS，Ik1通道的开放时间常数也缩短。结论维司力农对Ik1具有显著的抑制作用。这一效应可部分解释为何作为强心药的维司力农还同时具有抗心律失常作用。AIM To investigate the effect of potassium current (Ik1 ) in cultured embryonic 1×10-5 mol·L-1 vesnarinone on inward rectifier chick ventricular myocytes. METHODS Using cell-attached patch clamp technique. RESULTS The steady conductance of Ik1 channel was inhibited, the slope conductance was decreased from 28. 44 pS to 10. 77 pS and the open time constant was also shortened. CONCLUSIONS Vesnarinone has an obvious inhibited effect on Ik1, which may partially explain why vesnarinone as a cardiotonic agent has antiarrhythmic effect.

关 键 词：维司力农 心肌细胞 钾电流 膜片钳 

分 类 号：R972.1[医药卫生—药品]