Cu(Ⅱ)、Zn(Ⅱ)Schiff碱配合物的光谱分析及其对超氧离子的抑制作用  

Spectral Analysis of Cu(Ⅰ),Zn(Ⅱ) Complexes of Schiff Base and Their Dismutation to O_2^- Free Radical

作　　者：贤景春[1] 

机构地区：[1]泉州师范学院化学与生命科学学院,福建泉州362000

出　　处：《光谱学与光谱分析》2010年第3期725-728,共4页Spectroscopy and Spectral Analysis

基　　金：国家自然科学基金项目(20871054);福建省自然科学基金项目(Z0513017)资助

摘　　要：以水杨醛为原料,通过与混酸作用制备了5-硝基水杨醛,将其与盐酸氨基脲缩合制备出一种Schiff碱配体,用Cu(Ⅱ)和Zn(Ⅱ)分别与配体在70℃左右的恒温水浴中反应1.5 h,合成出了新型Schiff碱配合物。用元素分析、红外光谱、紫外光谱、差热热重、摩尔电导率、核磁共振等分析方法对化合物进行表征和测试,采用蛋氨酸光照法测定了配合物对超氧离子的催化歧化作用。结果表明,该Schiff碱配体及其配合物,组成确定,热力学稳定性高,在核黄素光照产生.O2-的体系中,配合物都表现出良好的生物活性,对超氧离子有很强的催化歧化作用,尤其是双配体铜配合物活性最强,对人红细胞内血红蛋白具有一定的保护作用。In the present paper a new 5 nitrosalicylaldehyde was prepared by the reaction of salicylaldehyde with mix acid, and this semicarbazide Schiff base ligand and its complex containing Cu （ Ⅱ ） and Ni （ Ⅱ ） were synthesized. Its compositions and structure were characterized by elemental analyses, thermal analyses, IR spectra and UV spectra, 1H NMR and molar conductivity. The dismutation to O2 free radical was also investigated. The result shows that the structure and thermodynamic properties were stable. The complexes showed a distinct O2^- scavenging effect and some protective effects on hemoglobin of human erythrocyte in the system of O2^- generating riboflavin with irradiation.

关 键 词：5-硝基水杨醛 SCHIFF碱 催化歧化作用 Cu(Ⅱ) Zn(Ⅱ) 

分 类 号：O641.4[理学—物理化学]