托吡酯对难治性癫痫基础药物治疗的增效作用观察  

To evaluate the efficacy of topiramate on patients with intractable epilepsy

作　　者：魏大萍[1] 陈峰[1] 雷雪[1] 

机构地区：[1]四川省广元市第二人民医院神经内科

出　　处：《实用医院临床杂志》2010年第1期61-62,共2页Practical Journal of Clinical Medicine

摘　　要：目的观察联用托吡酯(TPM)治疗难治性癫痫(IE)的疗效。方法32例连续正规治疗2年以上仍频繁发作的IE患者,在原用抗癫痫药的基础上加用TPM治疗,以加用TPM前3个月的月均发作频率为基数,与加用TPM后3个月的稳定期月均发作频率进行比较。结果加用TPM后月均发作频率(6±6)次,与加用TPM前3个月比较,差异有显著性意义(P<0.05),其中月均发作减少<50%有8例(25.00%),发作减少≥50%有24例(75.00%),发作减少≥75%有15例(46.88%),发作完全停止6例(18.75%)。结论联用TPM对IE基础药物治疗具有明显的增效作用。Objective To evaluate the efficacy of topiramate（TPM） on the patients With intractable epilepsy（IE）.Methods Thirty-two patients with IE entered an open add-on study with TPM and were given a follow-up.The efficacy was assessed by comparing the average frequency permonth of 3 months after TPM added up to maintenance period to the baseline therapy.Side effects were observed and analysed. Results Seizure frequency reduction by ≥50% was found in 75% of all patients,and ≥75% in 50% of all patients. Six patients （19%） became seizure-free. Conclusion The topiramate is effective for treating patients with IE.

关 键 词：托吡酯 难治性癫痫 疗效 

分 类 号：R971.6[医药卫生—药品] R742.105[医药卫生—药学]