N-十二烷基-N-甲基葡萄糖酰胺的合成  

Synthesis of N-Lauryl-N-methylglucamide

作　　者：袁航空[1] 李秋小[1] 李运玲[1] 

机构地区：[1]中国日用化学工业研究院,山西太原030001

出　　处：《精细化工》2010年第1期38-42,56,共6页Fine Chemicals

摘　　要：经过两步合成了N-十二烷基-N-甲基葡萄糖酰胺(MEGA-12)绿色表面活性剂。第1步葡萄糖与甲胺在Raney-Ni催化下经加氢还原胺化,得葡萄糖甲胺中间体,葡萄糖转化率100%;第2步以甲醇钠为催化剂,使葡萄糖甲胺与月桂酸甲酯酰胺化合成目标产物MEGA-12,葡萄糖甲胺转化率为94.12%。经单因素实验与正交实验,确定了最佳工艺条件,用FTIR和1HNMR对合成的中间体及目标产物进行了结构表征。A new type of green surfactant,N-lauryl-N-methylglucamide（MEGA-12）,was prepared via a two-step procedure.Firstly,the intermediate N-methylglucamine was synthesized by the reaction of D-glucose with methylamine and hydrogen in the presence of the Raney-Ni catalyst.Secondly,MEGA-12 was synthesized by the amidation of N-methylglucamine and methyl laurate using sodium methoxide as catalyst.The optimized conditions of the two-step procedure were obtained by the single factor experiment and orthogonal method.Finally,the structure of products were confirmed by FTIR and 1HNMR.

关 键 词：葡萄糖甲胺 N-十二烷基-N-甲基葡萄糖酰胺 合成 优化 表面活性剂 

分 类 号：TQ423.2[化学工程]