Brφnsted酸离子液体催化合成N-叔丁基苯乙酰胺  

Synthesis of N-Tert-butylphenylacetamide Catalyzed by Brφnsted Ionic Liquids

作　　者：赵地顺[1] 申晓冰[1] 李洪胜[2] 董兰芬[1] 吕斌[2] 

机构地区：[1]河北科技大学化学与制药工程学院,河北石家庄050018 [2]河北科技大学理学院,河北石家庄050018

出　　处：《精细化工》2010年第1期89-92,共4页Fine Chemicals

基　　金：国家自然科学基金项目(20576026);河北省自然科学基金项目(B2008000670)~~

摘　　要：合成并表征了Brφnsted酸离子液体,用于催化Ritter反应合成N-叔丁基苯乙酰胺。通过Hammett函数法测定了离子液体的H0值,[EPy]HSO4的酸性最强,H0为-0.04。通过考察4种离子液体的催化活性及重复使用性能,选定Brφnsted酸离子液体[EPy]HSO4为催化剂合成了N-叔丁基苯乙酰胺,得到较佳工艺条件为:反应温度50℃,反应时间6 h,收率达83.4%。分离后的离子液体经真空干燥后重复使用5次,催化活性没有下降。Brφnsted acidic ionic liquids were synthesized and characterized.The H0 was determined using the Hammett function.The acidity of HSO4 was the best.The H0 being-0.04.N-Tert-butylphenylacetamide was synthesized using the Ritter reaction by Brφnsted acidic ionic liquids.According to the study of catalytic activity and the reusability of various ionic liquids, HSO4 was chosen to synthesize N-tert-butylphenylacetamide as the catalyst.The optimal conditions were as follows：50 ℃,6 h.Under the optimal reaction conditions,the conversion could be 83.4%.The ionic liquids could be repeatedly used for five times after distillation and vacuum drying without considerable loss of activity.

关 键 词：Bφrnsted酸离子液体 Ritter反应 Hammett函数 N-叔丁基苯乙酰胺 精细化工中间体 

分 类 号：O625.4[理学—有机化学]