丝素-羟丙基壳聚糖微球的结构和释药性能  

The Structure and the Release Performance of Silk Fibroin-hydroxypropyl Chitosan Microspheres

作　　者：来水利[1] 王克玲[1] 张敏[1] 陈峰[1] 

机构地区：[1]陕西科技大学教育部轻化工助剂化学与技术重点实验室,陕西西安710021

出　　处：《精细化工》2010年第2期160-164,共5页Fine Chemicals

基　　金：陕西省咸阳市科技计划项目(XK06012-8)~~

摘　　要：以胰岛素为目标药物,以丝素(SF)和羟丙基壳聚糖(HPCS)为包药材料,复凝聚法制备SF-HPCS载药微球。采用红外光谱(FTIR)、扫描电镜(SEM)、X射线衍射(XRD)、热重分析(TGA)等对载药微球的结构、外部形貌及热性能等进行了表征。结果表明,所制备的载药微球表面密实,平均粒径22.4μm,呈正态分布;载药微球对胰岛素的包埋率达73.6%,大于HPCS载药微球(64.3%)及壳聚糖(CS)载药微球(57.1%);SF-HPCS载药微球在人工胃液中4h内累计释药率为21.3%,在人工肠液中24h内累计释药率达81.2%,48h累计释药率为92.2%,释放过程平稳、缓慢。Insulin was used as the targeting drugs package material, to prepare the SF Scanning electron microscopy （SEM） was drugs and silk protein and hydroxypropyl chitosan as the -HPCS microspheres using the complex coacervation. applied to observe the appearance of microspheres. The infrared spectroscopy （ FTIR）, scanning electron microscopy （ SEM ）, X-ray diffraction （ XRD ） and thermogravimetric analysis （TGA） were used to characterize the microspheres containing the drug structure,the external morphology and thermal properties. The results showed that microspheres were spherical, dense surface, and average particle size of 22.4 μm, normal distribution. There is an interaction between silk fibroin and hydroxypropyl chitosan. XRD showed that crystallization increased and the drug-loaded SF - HPCS microspheres embedded rate was 73.6%, larger than the drug-loaded HPCS microspheres （64. 3 % ） and the drug-loaded CS microspheres （57.1% ）. The drug-loaded SF - HPCS microsphere release of 21.3% in an artificial gastric juice,released 81.2% in 24 h. The release reached 92. 2% in 48 h in an artificial intestinal fluid. The process of drug release was slow.

关 键 词：丝素 羟丙基壳聚糖 载药微球 释药性能 医药原料 

分 类 号：O636.9[理学—高分子化学]