原发性肝癌双灌注介入治疗前后血清TNF-α和sFas水平的改变及意义探讨  

Hybrid Algorithm for Distortion Compensation of Space Target High Resolution Range Profiles

作　　者：杜小勇[1] 林晓烘[1] 王壮[1] 

机构地区：[1]国防科学技术大学,长沙410073

出　　处：《中国空间科学技术》2010年第1期52-59,共8页Chinese Space Science and Technology

摘　　要：目的了解原发性肝癌双灌注介入前后血清TNF-α、血清可溶性Fas（sFas）水平的变化,并探讨其临床意义。方法本研究选取75例原发性肝癌患者,其中30例行TACE治疗,45例行TACE联合脾动脉化疗药物灌注治疗,每个病例分别在术前一天、术后二周测定血清TNF-α、sFas,同时对所有病例进行近期疗效判定,另设30例正常对照组。结果肝癌患者的血清TNF-α和sFas的水平均明显高于正常对照组（P〈0.01）,TACE和双灌注治疗后血清TNF-α和sFas的水平均明显低于治疗前（P〈0.01）,双灌注治疗组治疗后血清TNF-α和sFas的水平分别低于TACE组治疗后水平（P〈0.05）,在双灌注组中,近期疗效达有效者血清TNF-α和sFas的水平明显低于无效者（P〈0.01）。结论原发性肝癌的双灌注介入治疗后血清TNF-α和sFas的水平明显降低,检测血清TNF-α和sFas的水平可以有助于预后估计。Distortion compensation of high resolution range （HRR） profiles plays an important role in ISAR imaging of space target with high speed. Since the ambiguity function＇s peaks of space target baseband echo lay on a cluster of parallel lines which contained the original, a multi-objective programming model was established based on the constraint bounds of the line cluster. After that, an analytic algorithm for velocity estimation was presented with the application of regularization principle. Furthermore, an iterative searching algorithm was applied to minimize the entropy of HRR profiles and a velocity estimator with higher precision was provided, where the proposed ana- lytic solution was set as the initial value for iteration. Simulations demonstrate that the proposed hybrid searching strategy takes the advantages of analytic algorithm and iteration algorithm in the computational complexity and estimate precision, which can effectively estimate the velocity of space target and compensate the distortion of HRR profiles.

关 键 词：原发性肝癌 肝动脉化疗栓塞 双灌注介入 TNF-Α SFAS 

分 类 号：Q255[生物学—细胞生物学] S858.285.3