封闭抗体的抗独特型抗体在反复自然流产中的应用价值  

THE APPLICATION OF THE ANTI IDIOTYPIC ANTIBODIES AGAINST BLOCKING ANTIBODIES TO RECURRENT SPONTANEOUS ABORTION

作　　者：孙晓溪[1] 李大金[1] 朱影[1] 王明雁[1] 孟毅 邵彦红 

机构地区：[1]上海医科大学妇产科研究所生殖免疫室

出　　处：《中国免疫学杂志》1998年第6期424-427,共4页Chinese Journal of Immunology

摘　　要：为了观察在反复自然流产（ＲＳＡ）中独特型抗体－抗独特型抗体网络的作用，分别测定正常生育组、原发性ＲＳＡ、继发性ＲＳＡ的封闭抗体效率（Ａｂ１）和抗独特型抗体（Ａｂ２），以及原发性ＲＳＡ免疫治疗前后Ａｂ２的变化。结果发现：正常生育组的Ａｂ１和Ａｂ２分别为７．５３％和１０．７０％；而原发性ＲＳＡ分别为－５５．５１％和－４２．６８％；继发性ＲＳＡ则分别为２９．９８％和－３０．００％，免疫治疗前后，原发性ＲＳＡ患者体内的Ａｂ２水平有明显差异，并随着免疫次数的增多，Ａｂ２水平有逐渐增高趋势。结果表明：原发性ＲＳＡ主要是因为体内缺乏ＴＬＸ的封闭抗体及其抗独特型抗体，而继发性ＲＳＡ仅显示封闭抗体的抗独特型抗体缺乏。因此封闭抗体的Ａｂ２可区分ＲＳＡ临床型并作为ＲＳＡ诊疗措施的重要指标。In order to investigate the role of the idiotypic antiidiotypic network in recurrent spontaneous abortion(RSA).Blocking antibodies(Ab 1) and their anti idiotypic antibodies(Ab 2) were analyzed in fertile women,primary and secondary aborters.It was found that the Ab 1 and their Ab 2 were 7.53% and 10.70%,in the fertile women,-55.51% and -42.68%,in the primary aborters,29.98% and -30.00% in the secondary aborters respectively.After immunization with leukocyte in primary RSA,the level of Ab 2 were significantly elevated,and increased gradually with the immunization times more.It was suggested that the primary RSA was due to lack of both Ab 1 and Ab 2,but the secondary RSA was only due to lack of Ab 2.Therefore,the antiidiotypic antibodies against blocking antibodies can be used to distinguished clinical subtypes of RSA,thus are important for diagnosis and treatment of RSA.

关 键 词：自然流产 封闭抗体 抗独特型抗体 免疫病理 

分 类 号：R714.210.3[医药卫生—妇产科学]