TGF-β胎盘定位及与妊高征发病关系  

LOCALIZATION OF TRANSFORMING GROWTH FACTOR BETA IN PLACENTA DURING NORMAL PREGNANCY AND WITH PREGNANCY INDUCED HYPERTENSION

作　　者：颜建华[1] 章容[1] 李望 姚宏[1] 陈竹钦[1] 

机构地区：[1]第三军医大学附属大坪医院妇产科

出　　处：《中国免疫学杂志》1998年第6期428-430,共3页Chinese Journal of Immunology

基　　金：国家自然科学基金

摘　　要：为确定胎盘ＴＧＦ－β的分布，探讨ＰＩＨ胎盘ＴＧＦ－β表达有无异常，用免疫组织化学染色观察了１０例早孕绒毛、１４例正常孕妇、４１例ＰＩＨ胎盘ＴＧＦ－β的分布。发现早孕绒毛滋养层细胞ＴＧＦ－β染色强阳性；晚孕期染色较早孕期显著减弱；绒毛外滋养层细胞ＴＧＦ－β阳性。ＰＩＨ患者绒毛滋养层细胞ＴＧＦ－β表达降低，且与病情程度相关。率先表明滋养层细胞存在ＴＧＦ－β的自分泌与旁分泌，ＴＧＦ－β表达受抑可能与ＰＩＨ发病有关。To determine the distribution of transforming growth factor beta in placenta during normal pregnancy and its possible changes in pregnancy induced hypertension(PIH),immunohistochemical localization exploring a TGF beta 1 antibody and Streptavidin/Peroxidase was applied to 10 first trimester chorionic villi,14 term normotensive controls and 41 PIH patients.Intensive staining was found to the cytoplasm of first trimester chorionic trophoblast while only moderately staining to term trophoblast.Extravillous term cytotropholast also stained with the antibody.The expression of TGF beta in PIH placentas were decreased in accordance with their severity.It was concluded that TGF beta might play important roles in pregnancy establishment and maintenance via autocrine and paracrine mechanisms and its abnormal expression might be related to the development of PIH.

关 键 词：转化生长因子Β 胎盘 妊娠高血压 综合征 

分 类 号：R714.246[医药卫生—妇产科学]