164例Coombs试验阳性的自身免疫性溶血性贫血的临床研究  

Clinical analysis of 164 cases Coombs test positive autoimmune hemolytic anemia

作　　者：张益枝[1,2,3] 储榆林[1,2,3] 陈桂彬[1,2,3] 林泽嬉 邵宗鸿[1,2,3] 

机构地区：[1]中国医学科学院,天津300020 [2]中国协和医科大学血液学研究所,天津300020 [3]血液病医院,天津300020

出　　处：《中华血液学杂志》1998年第11期573-575,共3页Chinese Journal of Hematology

摘　　要：目的:研究自身免疫性溶血性贫血(AIHA)的临床特征,进一步指导治疗。方法:采用回顾性分析患者资料,率的比较采用精确概率法,均值比较采用t检验。结果:AIHA多发生在女性,继发性占49％,以胶原系统疾病为主,Coombs分型以IgG+C_3型为主IgG+IgM阳性的患者临床表现最严重,环孢霉素A(CsA)联用皮质激素组有效率为90.9％。结论:皮质激素仍为治疗AIHA的首选药物,合用CsA可提高疗效,缩短疗程。Objective: To analyze the clinical features and treatment outcomes of autoirnmune hemolytic anemia (AIHA). Methods: Coombs test positive AIHA patients were retrospectively analyzed. Results: Pa- tients with AIHM were predominantly female, secondary AIHA accounted for 49% of the total cases, mainly associated with connective tissue diseases. In most cases of AIHA, the anti-red cell antibodies were IgG plus C_3, while patients with IgG plus IgM had more severe clinical manifestations. The response rate of adrenocortical hormones and cyclosporin A (CsA) was 90.9%. Conclusion: Adrenocorticosteroids is still the first choice of therapy for AM, CsA can improve the response rate.

关 键 词：溶血性贫血 AIHA 贫血 COOMBS试验 环孢霉素A 

分 类 号：R556.620.5[医药卫生—血液循环系统疾病]