阿仑膦酸钠联合辛伐他汀对老年性骨质疏松伴高脂血症患者的疗效观察  

The effect of Fosamax plus hypolipidemic drugs in treating osteoporosis in senile patients with hypolipidemic

作　　者：汪兰兰[1,2] 康冬梅[1,2] 

机构地区：[1]安徽医科大学附属省立医院 [2]安徽省立医院干部病房老年内分泌科,合肥230001

出　　处：《中国临床保健杂志》2010年第1期38-40,共3页Chinese Journal of Clinical Healthcare

基　　金：安徽省科技计划项目(08020303073)

摘　　要：目的观察阿仑膦酸钠片联合降血脂药物对伴有高脂血症的老年性骨质疏松患者的临床疗效。方法将42例老年性骨质疏松症伴高血脂患者分为三组,联合治疗组16例,口服阿仑膦酸钠片和辛伐他汀;阿仑膦酸钠片单独治疗组16例,仅服阿仑膦酸钠片;辛伐他汀单独治疗组10例,仅服辛伐他汀,观察6个月,观察治疗前后临床疗效、积分、腰椎及股骨颈的骨密度(BMD)和血脂等生化指标的变化。结果联合治疗组的总有效率为93.8%,明显高于阿仑膦酸钠片单独治疗组的86.7%(P<0.01)和辛伐他汀单独治疗组的0%(P<0.01)。三组治疗后BMD均有明显上升,但联合治疗组上升幅度大于单独治疗组(P<0.01)。联合治疗组和辛伐他汀治疗组的血脂下降明显,差异具有统计学意义(P<0.05),阿仑膦酸钠片单独治疗组的血脂也有下降,但无统计学意义。结论降血脂药物辛伐他汀对阿仑膦酸钠片治疗骨质疏松具有协同作用。Objective To study the effect of Fosamax plus hypolipidemic drugs treatment in senile patients with osteoporosis and hyperlipidemia. Methods 42 cases of senile osteoporosis with hyperlipidemia were divided into 3 groups, 16 patients took Fosamax plus Simvastatin as combined treatment group; Whereas individual treatment groups, 16 patients took Fosamax only as Fosamax group, 10 patients took Simvastatin only as Simvastatin group. The course of treatment was 6 months. The bone mineral density （BMD）and symptoms and lipid and other biochemical indicators were recorded before and after treatment. Results The total effective rate of combined treatment group was 93.8 %, significantly higher than that of Fosamax group （ 86.7%, P 〈 0.01 ） and Simvastatin group （ 0, P 〈 0.01 ）. In all the groups, BMD increased after treatment, and increased more in combined therapy than that in the drug treatment alone（ P 〈 0.01 ）. Lipid also significantly decreased in the combination therapy and simvastatin treatment group （P 〈 0. 05 ）. Conclusions Hypolipidemic drug combination treatment of simvastatin and Fosamax presents a synergy effect on osteoporosis.

关 键 词：骨质疏松 高脂血症 骨密度 二膦酸盐类 辛伐他汀 

分 类 号：R580[医药卫生—内分泌] R589.2[医药卫生—内科学]