蝎毒与吗啡中枢镇痛作用效果比较  

A Comparative Study on the Central Analgesic Effect of Scorpion Venom and Morphine

作　　者：李宁[1] 吕欣然[1] 韩惠蓉 朱庆磊[1] 李红军 于龙川[2] 

机构地区：[1]潍坊医学院应用药理学实验室,261042 [2]北京大学生命科学院

出　　处：《中草药》1998年第11期750-752,共3页Chinese Traditional and Herbal Drugs

摘　　要：蝎毒及其提取物有明显的镇痛作用，我们对其中枢镇痛作用效果与吗啡进行了比较。向大鼠中脑导水管周围灰质（PAG）内微量注射蝎毒（scorpionvenom，SV）和吗啡（morphine），以热辐射甩尾法为指标，观察比较二者中枢镇痛作用效果。结果表明：向大鼠PAG内恒速注射0．025％～0．10％SV0．5μL（相当于0．5μg／kg～2μg／kg）即出现痛阈升高，20min达峰值（痛阈最大提高150％以上），与对照组比较有显著差异（P＜0．01），而欲使大鼠痛阈提高150％，PAG内注射吗啡的用量约为10μg／kg。提示SV有很强的中枢镇痛作用，作用强于吗啡4倍以上。Central analgesic effect of scorpion venom (SV) and its extract were compared with that of morphine by injecting small amount of the test samples through periaqueductal gray (PAG) of rat and evaluated by flexion reflex caused by heat radiationi Results showed that the pain threshold increased over 150%20 minutes after doses equivalent to 0. 5 μg/kg to 2 μg/kg of SV, significantly different from the control (p<0.01). It was reported that injecting 10 μg/kg morphine through PAG will obtain the same potency. That is to say, the potency of SV is more than 5 times greater than that of morphine, and proved that SV is a potent central analgesic.

关 键 词：蝎毒 吗啡 镇痛作用 中枢镇痛 

分 类 号：R996.3[医药卫生—毒理学] R286.11[医药卫生—药学]