阿托伐他汀治疗老年糖尿病患者颈动脉粥样硬化临床观察  

Clinical Observation of Atorvastatin on Carotid Atheroma in Patients with Elderly Diabetes

作　　者：孙斌[1] 李来生[1] 刘林源[1] 高传玉[2] 

机构地区：[1]中国人民武装警察部队河南总队医院,郑州市450004 [2]河南省人民医院心内科,郑州市450003

出　　处：《医药论坛杂志》2010年第1期38-40,共3页Journal of Medical Forum

摘　　要：目的观察阿托伐他汀对2型糖尿病(T2DM)患者颈动脉内膜中膜厚度的影响。方法选择存在有不同程度的颈动脉粥样硬化并有斑块形成的老年2型糖尿病患者108例,随机分为2组。治疗组56例,给予阿托伐他汀10mg,每晚1次;对照组52例,给予肠溶阿司匹林100mg,每天1次,共6个月,观察治疗前后颈动脉内膜中膜厚度(CIMT)和斑块大小以及总胆固醇(TC)、甘油三脂(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)的变化。结果服用阿托伐他汀10mg 6个月后,治疗组颈动脉内膜中膜厚度及斑块较治疗前明显缩小(P<0.05),TC、TG、LDL-C水平明显降低,HDL-C水平明显升高(P<0.05);对照组治疗前后无明显差异(P>0.05)。结论阿托伐他汀可以明显减轻伴有颈动脉粥样硬化的老年2型糖尿病患者颈动脉粥样硬化病变,有效降低血脂水平,从而缩小动脉硬化进程。Objective To observe the clinical effect of atorvastatin on carotid atheroma in patients with elderly T2DM.Methods A total of 108 patients of elderly T2DM with carotid atheroma were randomly divided into two groups.The treatment group（n=56） was given orally 10 microgram of atorvastain every night;while the matched control group（n=52） was given 100 microgram aspirin of entericcoated every day for 6 months.Changes in serm total cholesterol（TC）,low density lipoprotein cholesterol（LDL-C）,triglyceride（TG）,high density lipoprotein cholesterol（HDL-C） and carotid arterial intima-meda thickness（CIMT） before and after treatment were investigated after six months.Results After six months of treatment,CIMT in atorvastatin group was reduced from（1.52±0.19） mm to（1.42±0.20） mm,and the levlels of TC and LDL-C in atorvastatin group was decreased than aspirin group（P〈0.05）.But there was no obvious change in the aspirin group（P〈0.05）.Conclusion Treatment by atorvastain can obviously decrease CIMT and TC and CDL-C,and ameliorate the carotid atheroma.

关 键 词：阿托伐他汀 2型糖尿病 颈动脉粥样硬化 动脉内膜中膜厚度 

分 类 号：R587.1[医药卫生—内分泌]