化痰五味散对慢性支气管炎模型作用的实验研究  

Effect of Expectorant Wuwei Pulvis on Chronic Bronchitis:An Experimental Study

作　　者：白旭华[1] 王洪涛 赵中华[1] 包桂兰[1] 王玉莹[1] 刘明洁[1] 于丽君[1] 强欣[1] 

机构地区：[1]内蒙古民族大学医学院,内蒙古通辽028041 [2]辽河镇动物防疫站,内蒙古通辽028000

出　　处：《中国现代医生》2010年第4期35-36,共2页China Modern Doctor

基　　金：内蒙古民族大学资助项目(编号MDK2007054)

摘　　要：目的通过实验观察化痰五味散对慢性支气管炎模型的作用。方法采用豚鼠组胺引喘实验、豚鼠离体气管条实验、小鼠二氧化硫引咳实验及抗炎实验,对化痰五味散的平喘、止咳、抗炎作用进行实验研究。结果化痰五味散可明显延长引喘潜伏期,对组胺引起的豚鼠离体气管条收缩具有较好的抑制作用,明显延长二氧化硫所致小鼠的咳嗽潜伏期,具有改善慢性支气管炎性病变的作用。结论化痰五味散具有明显平喘、止咳、抗炎作用,可用于慢性支气管炎的治疗。Objective To investigate the effects of expectorant Wuwei pulvis on chronic bronchitis. Methods An experimental study was made of the antitussive and antiasthmatic and anti-inflammatory effects of expectorant Wuwei Pulvis by using guinea pig histamine experiments, guinea-pig isolated tracheal strips in vitro experiments, mouse experiments of sulfur dioxide cited cough and anti-inflammatory experiments. Results The expectorant Wuwei pulvis could obviously prolong the latent period of asthma and had the significant inhibition of the contraction of guinea-pig isolated tracheal strips induced by histamine. It could obviously prolong the latent period of mouse cough induced by sulfur dioxide and had the improvement of inflammatory lesions of chronic bronchitis. Conclusion The expectorant Wuwei pulvis has significant antiashmatic, antitussive and anti-inflammatory effects, and can be used in the treatment of chronic bronchitis.

关 键 词：化痰五味散 慢性支气管炎模型 实验研究 

分 类 号：R562.11[医药卫生—呼吸系统] R285.5[医药卫生—内科学]