D-二聚体检测在儿童肾脏病中的意义  

The Significance of Determination of Plasma D-Dimer in Children with Nephropathy

作　　者：诸葛洪[1] 林国珍[1] 顾盘仙[1] 王学锋[2] 王钦红[3] 

机构地区：[1]上海第二医科大学附属瑞金医院儿内科,200025 [2]上海第二医科大学附属瑞金医院出凝血实验室 [3]上海第二医科大学附属瑞金医院血液研究所

出　　处：《上海第二医科大学学报》1998年第6期486-488,共3页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：运用国产试剂盒对47例儿童肾脏病患者及15例正常健康儿进行血浆 D-二聚体和血 FDP 测定并对15例。肾病患儿在应用抗凝治疗前后作动态检测。结果不同。肾病患儿血 D-二聚体值均高于正常儿组,其中以肾病组升高更为显著(P<0.01);15例肾病患儿动态检测结果表明经过抗凝治疗后血 D-二聚体值下降并接近正常。结果提示:在无临床栓塞表现的儿童肾脏病测定 D-二聚体可间接预测高凝状态存在,并可作抗凝药物治疗的依据和预后估计。We studied the concentration of plasma D-Dimer in 47 children with renal diseases and observed the changes of plasma D-Dimer levels in 15 children with nephrotic syndrome before or after anticoagulation treatment.The results showed that the concentration of plasma D-Dimer in patients of renal disease was significantly higher than that in control group.After anticoagulation treatment the raised concentration of plasma D-Dimer returned to normal in 15 patients of nephrotic syndrome.Thus we suggest that determination of plasma D-Dimer could be used as an indicator of hypercoagulation state and in the anticoagulation treatment in nephrotic syndrome.

关 键 词：D-二聚体 肾病综合征 肾炎 紫癜性肾炎 儿童 

分 类 号：R726.92[医药卫生—儿科]