非淋病性尿道炎患者支原体检测及药敏分析  

Analysis and drug sensitivity test of mycoplasms in non-gonococcal urethritis patients

作　　者：范芳华[1] 肖震[1] 于小妹[1] 严杰[2] 

机构地区：[1]浙江医院检验科,浙江杭州310013 [2]浙江大学医学院病原生物学系

出　　处：《全科医学临床与教育》2010年第1期26-28,共3页Clinical Education of General Practice

摘　　要：目的了解医院泌尿生殖系统炎性患者中解脲支原体(Uu)和人形支原体(Mh)的分离情况及其对抗菌药物的敏感性。方法采用法国生物梅里埃公司的MycoplasmaIST试剂盒对非淋病性尿道炎(NGU)患者泌尿生殖道标本进行支原体分离培养及药敏检测。结果248例NGU患者中检出支原体142例,阳性率为57.26%。其中男性标本阳性率为44.00%,女性为60.61%,男、女阳性率比较,差异有统计学意义(χ2=4.50,P<0.05)。142例阳性标本中Uu+Mh混合感染阳性102例(71.83%),单纯Uu阳性38例(26.76%)及单纯Mh阳性2例(1.41%)。女性感染者中Uu+Mh混合感染比例为75.00%,男性54.55%,男、女Uu+Mh混合感染阳性率差异有统计学意义(χ2=3.85,P<0.05)。药敏显示Uu+Mh混合感染的耐药率总体上明显高于单纯Uu;单纯Uu感染对强力霉素、克拉霉素和交沙霉素最为敏感;Uu+Mh混合感染对强力霉素、交沙霉素和原始霉素较敏感。结论Uu+Mh混合感染阳性率较高,对抗生素的耐药率也更高,应引起临床医生重视,根据药敏试验结果合理选用抗生素。Objective To study the isolation and drug sensitivity of Ureaplasma urealyticum （Uu） and Mycoplasma hominis （Mh） from the patients with phlegmonosis in genitourinary system. Methods An integrated IST kit isolation identification and drug resistance test of mycoplasma from genital tract of NGU patients was used. Results The isolates of mycoplasma was 142 strains in 248 NGU patients, the positive rate was 57.26%, and 44.00% was from male, the other 60.61% from female. The difference of positive rate in gender was statistical significance （X^2=4.50 ,P〈 0.05）. From the positive specimens of 142 cases the infection of Uu was 38 cases （26.76%）, Mh was 2 cases （1.41%）, and the mixed was 102 cases （71.83%）. The positive rate of patients infected with mixed state of Uu＋Mh was significantly higher in female （75.00%） than that in male（54.55%）, （X2=3.85,P〈0.05）. The drug resistance of Uu and Mh mix infection was higher than that of Uu; Uu infection was much sensitive to Josamyein （JOS）, Doxyeycline（DOX） and Clarithromycin（CLA）; Uu ＋ Mh were sensitive to JOS, DOX and Pristinamycin（PRY）. Condusions The positive rate of Uu and Mh mix infection was high in patients with phlegmonosis in genitourinary system ; its drug resistance was higher than the drug resistance of Uu infection. Clinicians should pay more attention and select antibiotics according to the drug susceptibility test.

关 键 词：非淋病性尿道炎 解脲支原体 人形支原体 药敏试验 

分 类 号：R446.5[医药卫生—诊断学] R695[医药卫生—临床医学]