缓释氟粘贴片的体外释放规律  

Releasing character of slow - release fluoride tablet in vitro

作　　者：葛瑶[1] 王勤[1] 

机构地区：[1]北京医科大学口腔医学院防龋研究室,100081

出　　处：《现代口腔医学杂志》1998年第4期279-281,共3页Journal of Modern Stomatology

基　　金：国家"八五"科技攻关项目(85-925-06-02)

摘　　要：为实现高频率、低浓度、长时间使用氟化物,我们研制了一种缓释氟粘贴片。在体内能够缓慢释放使唾液氟离子浓度升高时间约为2.5～6.0小时。目的:因为体内研究有诸多不便,我们希望能在体外进行实验,它的结果能反应体内的情况。本文就是要建立一个体外系统,分析氟粘贴片在其中的释氟情况,并与体内释氟规律相比较。方法:本文建立了一个模仿口腔内唾液流动的体外滴定系统,它有4个组成部分:人工唾液储库、导管系统和控制阀、中瓶和搅拌器、总量瓶。实验在室温下进行,人工唾液流速为720～800ml/d。缓释氟粘贴片投入其中,于放药后15、30分钟、1、2、3、4、5小时各取1ml溶液测定氟离子浓度。结果:氟粘贴片在体外滴定系统中的释氟规律基本上与体内类似,但必须控制氟粘贴片体外作用时间在4小时以内。结论:本实验建立的体外滴定系统,为今后防龋含氟制剂的体外研究开辟了一个新的研究方法。In order to find the most beneficial method to applying fluoride, we have developed a new kind of fluoride tablet which could release fluoride ion for 2.5 to 6.0 hours in vivo. Objective: We want to establsh a titration system imitating oral condition to avoid many inconvenient in vivo when doing experiment in this research. Methods:This constant titration system made up of four parts:reservoir of artifical saliva;duct system and valves;middle bottle and stirrer;bottle for whole volume. Releasing character of fluoride tablet was studied by determined fluoride ion's concentration of artifical saliva in middle bottle at different intervals. Results: Fluoride releasing in this system is comparable with that in vivo within 4 hours. Conclusions: A constant titration system set up in this research provides a new way for fluoride preparations study in vitro.

关 键 词：缓释片 龋齿 缓释氟粘贴片 体外释放 

分 类 号：R988.2[医药卫生—药品] R780.1[医药卫生—药学]