不同疗程含异烟肼、利福平方案对尘肺结核近远期疗效观察  

Efficacy of regimens containing INH,RFP with varied chemotherapy courses on retreated culture positive pneumoconio tuberculosis

作　　者：蒋文忠[1] 陈怀华[1] 高劲松[1] 

机构地区：[1]安徽省淮北矿务局职业病防治院

出　　处：《中华结核和呼吸杂志》1998年第11期648-650,共3页Chinese Journal of Tuberculosis and Respiratory Diseases

摘　　要：目的探讨以ＨＲ为主不同疗程化疗方案对菌阳尘肺结核的近远期疗效。方法将７９例菌阳病例分为９月组（Ｍ９：２ＳＨＲＺ／７ＨＲＥ）、１２月组（Ｍ１２：２ＳＨＲＺ／１０ＨＲＥ）、１８月组（Ｍ１８：２ＳＨＲＺ／１０ＨＲＥ／６ＨＲ），分别采用不同方案治疗。疗效考核以痰菌为主要依据。满疗程随访５～８年。结果Ｍ９、Ｍ１２、Ｍ１８组满疗程痰菌阴转率分别为８３％、９６％、９５％，随访期间痰菌复阳率分别为４１％、４％、５％，其中随访１～４年痰菌复阳率分别为６％、８％、２％、２％，第５～８年无复阳病例。结论１２月方案（２ＳＨＲＺ／１０ＨＲＥ）对复治菌阳尘肺结核有效；随访时间以４～５年为宜。Objective To evaluate the short and long term effects of regimens containing INH、RFP with varied chemotherapy courses on culture positive pneumoconio tuberculosis. Method 79 patients with culture positive pneumoconio tuberculosis were divided into three groups according to chemotherapy duration: 9 months group(M9:2SHRZ/7HRE) 28 cases,12 month group(2SHRZ/10HRE) 25 cases, 18 month group(M18:2SHRZ/10HRE/6HR)26cases.Evaluating the efficacy of regimens depended predominantly on sputum bacteriological conversion, and the patients who completed the regimens were followed up for 5～8 years. Result Sputum negative conversion rates of three groups at the end of chemotherapy were 83%, 96%, 95%,and their recurrent rates in follow up period 41%, 4% and 5% respectively.Of all patients who completed the regimens bacteriological relapse rates from the first to fourth year are 6%, 8%, 2%, 2% in the follow up period.There was no bacteriological relapse from fifth to eighth year. Conclusion It is effective for SHRZ/HRE combination with 12 months course to retreated tubercle bacillus positive pneumoconio tuberculosis, and it is appropriate for such patients to be followed up for 4～5 years.

关 键 词：尘肺结核 肺结核 药物疗法 异烟肼 利福平 

分 类 号：R521.05[医药卫生—内科学]