补骨胶囊对SLE患者激素治疗后骨质疏松的作用及细胞因子表达的影响  

The Effect of Bugu Capsule on Osteoporosis of Systemic Lupus Erythematosus by Glucocorticoid Therapy and Expxession of Cytokines

作　　者：史建强[1] 陈丽娟[1] 许宗严[1] 陈秋霞[1] 李定[1] 林光平 

机构地区：[1]广东医学院附属医院皮肤性病科,广东湛江524001 [2]廉江市新民医院,广东廉江524441

出　　处：《中国皮肤性病学杂志》2010年第2期169-171,共3页The Chinese Journal of Dermatovenereology

基　　金：湛江市科技攻关项目(湛科[2005]43号06)

摘　　要：目的探讨中成药补骨胶囊对系统性红斑狼疮(SLE)患者激素治疗后骨质代谢及细胞因子表达的影响。方法66例SLE患者随机分为两组,治疗组34例,采用糖皮质激素和补骨胶囊治疗;对照组32例,单纯采用糖皮质激素治疗,另设健康组30例。观察治疗前后两组病人IL-1,IL-6,TNF-α表达水平和血钙、磷、碱性磷酸酶、甲状旁腺素的变化以及三角区骨密度的改变,并与健康组对照比较。结果治疗前两组病人的各项指标差异均无显著性;治疗后两组患者的IL-1,IL-6,TNF-α表达水平和血钙、甲状旁腺素的变化以及三角区骨密度的改变,差异均有显著性(P<0.01或P<0.05)。结论中成药补骨胶囊能有效防治由糖皮质激素致患者骨质疏松的发生,其作用机制可能与调节患者体内细胞因子IL-1,IL-6,TNF-α表达水平和甲状旁腺素的分泌有关。Objective To investigate the effect of Bugu capsules on the osteoporosis and expression of cytokinein in systemic lupus erythematosus （SLE） patients. Methods Sixty-six cases with SLE were divided into two groups randomly： Treatment group consisted of 34 cases which were treated with glucocorticoid and Bugu capsules, while control group of 32 cases were treated with glucocorticoid only. All patients were evaluated by determination of bone mineral density （BMD） and related biochemical parameters such as serum calcium, serum P, serum ALP and serum parathyroid hormone（PTH） before and after treatment. IL-1, IL-6 and TNF-α were detected before and after treatment in two groups. Results The changes of serum Calcium, PTH and BMD between pre-treatment and post-treatment in two groups were significantly different （P 〈 0.01 ）. The levels of IL-1 ,IL-6 and TNF-α showed significant difference in two groups （P 〈0. 01 or P 〈0. 05 ）. Conclusion Mechanism of Bugu capsules in the treatment of osteoporosis in SLE patients may involve the regulation of serum Ca , serum PTH and down regulation the levels of IL-1, IL-6 and TNF-α.

关 键 词：系统性红斑狼疮 骨质疏松 补骨胶囊 糖皮质激素 并发症 

分 类 号：R593.24[医药卫生—内科学] R285.6[医药卫生—临床医学]