骨髓间充质干细胞修复脊髓损伤的临床研究现状  

Expression of bone marrow-derived mesenchymal stem cells in spinal cord injury

作　　者：高德萱[1] 贾全章[1] 

机构地区：[1]解放军第208医院骨一科,长春130016

出　　处：《中国矫形外科杂志》2010年第4期291-293,共3页Orthopedic Journal of China

基　　金：吉林省科技发展计划项目(编号:20080446)

摘　　要：脊髓损伤是造成截瘫的主要原因和人类致残率最高的疾患之一,近几年的动物实验显示BMSCs在治疗SCI中有着良好的应用前景,这些研究成果日益引起国内外学者们的关注,并尝试将其应用于临床,取得了一定的疗效,但长期效果有待随访观察。临床治疗时BMSCs植入的最佳时间为SCI后第9 d左右,常用方法有:(1)细胞悬液损伤部位直接注射法;(2)腰穿(经脑脊液)细胞悬液注射法;(3)静脉内细胞悬液输入法;(4)诱导分化后移植。BMSCs移植治疗脊髓损伤的研究刚起步,困难和问题仍然很多,但随着该领域基础研究、临床试验成果和经验的不断积累,BMSCs极有可能在脊髓损伤治疗这一世界难题中发挥出不可替代的作用。Spinal cord injury is the main reason for paraplegia and one of the highest diseases causing human disability.Recent animals researches shows BMSCs has a good prospect in curing SCI,and these researches attracted doctors＇ attention from home and abroad,and they had achieved a certain effect,but long-term effects needs follow-up observation.In clinical the best time for transplanting BMSCs is about 9 days after SCI.Common methods：（1）Cell suspension injecting damaged parts directly.（2）Lumbar puncture cell suspension input.（3）Intravenous cell suspension input.（4）After the induced differentiation cell suspension.But with the development of basic research and clinical trial results,BMSCs could play an irreplaceable role in the treatment of spinal cord injury.

关 键 词：骨髓间充质千细胞 脊髓损伤 临床 

分 类 号：R651.2[医药卫生—外科学]