新型肺动脉带瓣管道移植动物实验与血流动力学评价  

Animal experiments of valve replacement with bioprosthetic pulmonary valve conduit

作　　者：李子林[1,2] 刘金成[1] 段维勋[1] 易定华[1] 

机构地区：[1]第四军医大学西京医院心血管外科,陕西西安710032 [2]解放军第452医院心胸外科,四川成都610061

出　　处：《心脏杂志》2010年第2期180-182,共3页Chinese Heart Journal

基　　金：国家863科技计划攻关重大课题(2006AA02A138)资助

摘　　要：目的:对我们与佰仁公司共同研制的肺动脉带瓣管道进行犬移植实验并进行血流动力学评价。方法:肺动脉带瓣管道在体外循环辅助心脏不停跳下对犬行肺动脉瓣置换术,术后持续监测生命体征,术中及术后观察瓣膜血流动力学变化。结果:8条犬6条存活,且存活均超过1个月,存活个体状态良好。死亡的犬中1条由于呼吸机故障,1条可能与瓣膜不匹配有关。手术前后无明显血流动力学变化,手术后右室-肺动脉无明显压差。结论:新型改良肺动脉带瓣管道植入实验犬是适合的。新型肺动脉带瓣管道已显示出优良的血流动力学优势。AIM： To assess hemodynamic performance of right ventricular outflow tract and pulmonary artery reconstruction （RV-PA） in dogs. METHODS： Eight adult dogs underwent implanted bioprosthetie pulmonary valved conduit in pulmonary position under cardiopulmonary bypass with beating heart. Right ventrieular and pulmonary artery pressures were measured directly before and after implantation. RESULTS： Six adult dogs survived in good condition after surgery and survived 1 month after implantation. One dog died from mismatch of prosthetic valve at postoperative day 10. The other dog died due to respiratory failure . The mean gradient was not different significantly between discharge and the post-operation. CONCLUSION： The new bioprosthetic pulmonary valve conduit shows good performance in animal experiments and good short-term hemodynamic performance.

关 键 词：肺动脉带瓣管道 肺动脉瓣 犬 移植 血流动力学 

分 类 号：R617[医药卫生—外科学]