2型糖尿病患者内脂素水平与颈动脉内中膜厚度相关  

Association between plasma visfatin and intima-media thickness of carotid artery in patients with type 2 diabetes

作　　者：高丽华[1] 赵占胜[1] 田晖[2] 吴冰洁[3] 贾丽梅[3] 王绵[1] 邓永贵[1] 周红[1] 张力辉[1] 苏胜偶[1] 

机构地区：[1]河北医科大学第二医院内分泌科,石家庄050000 [2]河北医科大学第二医院功能科,石家庄050000 [3]河北医科大学第二医院体检中心,石家庄050000

出　　处：《中华内分泌代谢杂志》2010年第1期15-16,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：基金项目：河北省二00七年医学科学研究重点课题计划（07072）

摘　　要：73例2型糖尿病患者，根据颈动脉内中膜厚度（IMT）分为动脉粥样硬化（AS）组和非As组，测定血浆内脂素水平。结果显示，2型糖尿病AS组内脂素水平高于非AS组[（44．95±10．14对34．52±9．08）ug／L，P〈0．05]，均高于对照组[（24．46±7．18）ug／L，均P〈0．05]，并与IMT、腰臀比、内脏脂肪厚度、空腹胰岛素、胰岛素抵抗指数呈正相关。年龄、病程、HbA1c及内脂素是影响颈动脉IMT的相关因素。Seventy-three patients with type 2 diabetes mellitus were divided into atheroselerosis （AS） group and non-AS group aeeording to the intima-media thickness（IMT） of the carotid artery. The plasma visfatin level in AS group was higher than that in non-AS group [ （44.95 ± 10. 14 vs 34.52± 9.08 ） ug/L, P〈 0.05 ] , and both of them were higher than that of the control [ （24.4±7.18） ug/L, both P〈0.05 ]. The visfatin level was positively correlated with IMT, waist-to-hip ratio, visceral fat thickness, fasting insulin, and HOMA insulin resistance index. Age, duration of diabetes, HbA1c, and visfatin level were the major risk factors for IMT of the carotid artery.

关 键 词：内脂素 糖尿病 2型 动脉粥样硬化 颈动脉内中膜厚度 

分 类 号：R587.1[医药卫生—内分泌]