N-二氯乙酰基-3,6-二甲基-3-乙基-9-氧代-1,5-二氮杂二环[4.3.0]壬烷的合成及生物活性研究  

Synthesis and biological activity of 5-dichloroacetyl-3,6-dimethyl-3-ethyl-9-oxo-1,5-diazabicyclo[4.3.0] nonane

作　　者：孙太凡[1] 叶非[2] 冯世德[1] 

机构地区：[1]黑龙江八一农垦大学文理学院,黑龙江大庆163319 [2]东北农业大学理学院,黑龙江哈尔滨150030

出　　处：《分子科学学报》2010年第1期58-61,共4页Journal of Molecular Science

基　　金：黑龙江省自然科学基金资助项目(B200602);哈尔滨市科技创新人才研究专项资金项目(2006RFXXN005)

摘　　要：合成了新型除草剂安全剂N-二氯乙酰基-3,6-二甲基-3-乙基-9-氧代-1,5-二氮杂二环[4.3.0]壬烷.以丁酮为原料,与硝基甲烷作用,制得二硝基化合物,然后将其还原,还原产物与乙酰丙酸成环,再与二氯乙酰氯反应,即得到标题化合物.采用红外光谱、核磁共振谱和元素分析对产物进行了结构表征,并利用土培法对其进行了初步的生物活性测定.结果表明:化合物能够减轻绿磺隆对玉米的伤害.A novel herbicide safener N-Dichloroacetyl-3,6-dimethyl-3-ethyl-9-oxo-1,5-diazabicyclo[4.3.0] nonane was synthesized.The 2-methyl-2-ethyl-1,3-dinitropropane was synthesized with butanone and nitromethane, then it was reduced, 2-methyl-2-ethyl-1,3-propanediamine was obtained. The title compound was synthesized by the reaction of 2-methyl-2-ethyl-1,3-propanediamine with levulinic acid and dichloroacetyl chloride. It was characterized by IR, 1H NMR and elemental analysis. The preliminary biological test showed that the compound protected maize against injury by chlorsulfuron.

关 键 词：除草剂安全剂 合成 生物活性 

分 类 号：O626[理学—有机化学]