右旋布洛芬缓释片的含量测定及体外释放特性研究  

Content Determination of Dexibuprofen Sustained Release Tablets and Its in vitro Release Characteristics

作　　者：尹辉[1] 胡容峰[1] 高宇[1] 徐亚静[1] 

机构地区：[1]安徽中医学院药学院现代中药安徽省重点实验室,安徽合肥230031

出　　处：《安徽中医学院学报》2010年第1期60-63,共4页Journal of Anhui Traditional Chinese Medical College

基　　金：安徽省高等学校省级自然科学研究项目(KJ2009A112)

摘　　要：目的建立右旋布洛芬缓释片的含量测定方法，并评价其体外释放特性。方法采用高效液相色谱法测定缓释片含量，采用紫外分光光度法对缓释片的体外释放特性进行研究。结果右旋布洛芬在4-100μg／ml范围内线性关系良好（r=0．9995），平均回收率为99．44％，RSD=0．94％。释放行为显示右旋布洛芬缓释片呈零级释放，药物释放被延长到12h。结论本方法准确可靠，重现性好，灵敏度高，可用于右旋布洛芬缓释片的质量控制。所研制的右旋布洛芬缓释片达到了缓慢释放药物的目的。Objective To establish a method for content determination of Dexibuprofen Sustained Release Tablets and evaluate its release characteristics in vitro. Methods The content of Dexibuprofen Sustained Release Tablets was determined by high performance liquid chromatography, and its in vitro release characteristics were evaluated by ultraviolet spectrophotometry. Results Dexibuprofen Sustained Release Tablets showed a good linear relationship at a range of 4-100 μg/ml, r=0. 999 5. The average recovery was 99.44%,RSD=0. 94%. The release behavior of Dexibuprofen Sustained Release Tablets conformed to zero-order kinetics, and drug release time was extended up to 12 hours. Conclusion This method can be used for the quality control of Dexibuprofen Sustained Release Tablets because of its accuracy,good reproducibility and high sensitivity. The prepared Dexibuprofen Tablets has the characteristic of sustained release.

关 键 词：右旋布洛芬 缓释片 累计释放度 高效液相色谱法 

分 类 号：R927.2[医药卫生—药学]