原发性高血压患者血清半胱氨酸蛋白酶抑制剂C的临床意义  

The Detection and Clinical Significance of Serum Cystatin C in Primary Hypertension Patients

作　　者：贾勤 

机构地区：[1]湖北省老河口市第一医院心血管内科,441800

出　　处：《实用心脑肺血管病杂志》2010年第2期145-146,共2页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的观察原发性高血压患者血清半胱氨酸蛋白酶抑制剂C(Cyst-C)的水平,并探讨其临床意义。方法检测368例原发性高血压患者血清Cyst-C、β2-微球蛋白(β2-MG)和肌酐(Cr)水平,并与正常对照组的测定结果进行比较。结果368例原发性高血压患者中,血清Cyst-C、β2-MG与Cr均增高者82例,与对照组比较差异均有统计学意义(P<0.05);血清Cyst-C、β2-MG增高而Cr正常者105例,与对照组比较血清Cyst-C、β2-MG差异有统计学差异(P<0.05),血清Cr差异无统计学意义(P>0.05);血清Cyst-C增高而β2-MG、Cr正常者181例,与对照组比较血清Cyst-C差异有统计学意义(P<0.05),血清β2-MG、Cr差异无统计学差异(P>0.05)。结论原发性高血压患者血清Cyst-C检测有助于早期肾功能损害的发现。Objective To study the level of serum cystatin C （ Cyst - C） in primary hypertension patients and explore its＇ clinical significance. Methods Serum cystatin C （ Cyst - C） , β2-MG and Cr were detected in 368 patients with primary hypertension. Results Among 368 primary hypertension patients, serum eystatin C （Cyst - C） , β2- MG and Cr were elevat- ed in 82 cases; 105 cases had both elevated serum c ystatin C （Cyst -C） and elevated β2-MG, but normal Cr; 181 cases had elevated serum cystatin C （ Cyst - C ） , but both normal β2- MG and normal Cr. Conclusion Serum Cyst - C detection may be useful for the finding of early stage renal disfunction in primary hypertension patients.

关 键 词：高血压 肾功能 Cyst-C Β-微球蛋白 肌酐 

分 类 号：R544.1[医药卫生—心血管疾病]