补肾泻肝汤对前列腺组织Smad2、Smad4表达的影响  

Effect of Bushenxiegan Prescription on the Expression and Significance of Smad2 and Smad4 in Benign Prostatic Hyperplasia Tissues

作　　者：曹继刚[1] 周安方[1] 赵刚[1] 王进[1] 黄琼霞[1] 舒劲松[1] 周艳艳[1] 邹锋[1] 

机构地区：[1]湖北中医学院基础医学院,湖北武汉430065

出　　处：《中医药学报》2010年第1期14-17,共4页Acta Chinese Medicine and Pharmacology

基　　金：国家自然科学基金(30973704);湖北省自然科学基金(2007ABA057);武汉市科技晨光计划(200850731346);湖北省教育厅中青年项目(Q20081601)

摘　　要：目的:观察补肾泻肝汤对实验性大鼠前列腺增生组织Smad2和Smad4表达的影响及意义。方法:去势加丙酸睾酮注射法复制大鼠前列腺增生模型,免疫组织化学法检测大鼠前列腺增生组织及正常前列腺组织Smad2和Smad4的表达。结果:模型组大鼠前列腺组织Smad2和Smad4表达水平均下调,不论Smad2还是Smad4,其在前列腺增生组织中的阳性表达率与正常前列腺组织及补肾泻肝汤组阳性表达率比较,差别有显著意义(P<0.05)。结论:Smad2和Smad4参与了前列腺增生的病理过程,补肾泻肝汤对前列腺增生组织Smad2和Smad4表达的改变有调节作用。Objective：To observe the effect of Bushenxiegan prescription on the expression of Smad2 and Smad4 in benign prostatic hyperplasia tissues.Methods：S.D male rats were castrated,then subcutaneous injected testosterone propionate for 30 days.The expression of Smad2 and Smad4 levels in tissues of benign prostatic hyperplasia and normal prostate were detcted by immunohistochemiscal method.Results：The expression level of Smad2 in benign prostatic hyperplasia tissues and Smad4 is lower than that in normal prostate（P〈0.05）.Conclusion：The expression level of Smad2 and Smad4 in benign prostatic hyperplasia tissues is lower than that in normal prostate.Both of them might be involved in the development of benign prostatic hyperplasia tissues.Bushenxiegan prescription can regulate the the expression of Smad2 and Smad4 of benign prostatic hyperplasia.

关 键 词：前列腺增生 SMAD2 SMAD4 补肾泻肝汤 

分 类 号：R697.33[医药卫生—泌尿科学]