由对硝基甲苯合成对羟基苯甲醛的工艺改进  

Improved Synthesis Technology of p-Hydroxybenzaldehyde from p-nitrotoluene

作　　者：周辉[1,2] 董世昌[1,2] 李立威[2] 

机构地区：[1]武汉工程大学化工与制药学院,湖北武汉430073 [2]荆楚理工学院化工与药学院,湖北荆门448000

出　　处：《中国药业》2010年第6期16-17,共2页China Pharmaceuticals

摘　　要：目的改进对羟基苯甲醛的合成工艺。方法以对硝基甲苯为原料,通过与Na2SX氧化还原反应合成对氨基苯甲醛,不经分离直接进行重氮化及水解制得对羟基苯甲醛,无需有机溶剂进行产物萃取。结果总收率为82%。结论改进后的工艺收率高,操作步骤更简单,更适宜于规模化生产。Objective To improve the synthesis technology of p-hydroxybenzaldehyde. Methods The reduction of p-nitrotoluene by sodium polysulfide produced p-aminobenzaldehyde. The reaction solution, without separation, was directly used for synthesis of p-hydroxybenzaldeyde, and there was no need to use organic solvents for extraction of final product. Results The total yield was 82%. Conclusion The improved process with high yield is simple and convenient to operation, and hence it is more suitable for scale-up production.

关 键 词：对硝基甲苯 氧化还原 重氮化 对羟基苯甲醛 

分 类 号：TQ460.3[化学工程—制药化工]