外周血白细胞与冠状动脉狭窄程度及冠心病中医证型之间的关系  

Relationship among Peripheral Leucocytes,Coronary Stenosis and Chinese Medicine Syndromes in Patients with Coronary Heart Disease

作　　者：王阶[1] 李霁[1] 杨戈[1] 

机构地区：[1]中国中医科学院广安门医院,北京100053

出　　处：《中国中西医结合杂志》2010年第2期130-132,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：北京市自然科学基金项目(No.7062058);活血化瘀药对不稳定型心绞痛血瘀证凋亡因子的影响973课题(No.2003CB517103);冠心病病证结合诊断标准及疗效评价体系的研究优势病种(No.CACMSO5Y0010)

摘　　要：目的探讨外周血白细胞与冠状动脉(冠脉)狭窄程度及冠心病中医证型之间的关系。方法189例冠心病患者辨证分为痰浊血瘀证、气虚血瘀证、寒凝血瘀证、气滞血瘀证、气虚痰瘀证和痰浊阻络证6型。同时进行冠脉造影及外周血白细胞的测定,采用血瘀证积分评定血瘀证程度,采用Gensini评分系统分析冠脉造影的结果,对其结果进行统计分析。结果血瘀证积分寒凝血瘀证最高,且冠脉狭窄程度最高,其后依次为痰浊血瘀、气虚血瘀、气滞血瘀证,非血瘀证组的痰浊阻络和气虚痰凝证冠脉狭窄程度最低。外周血白细胞与血瘀证积分及Gensini积分相关,且单核细胞与血瘀证的积分独立相关,中性粒细胞与Gensini积分独立相关。结论血瘀证积分、外周血中性粒细胞、单核细胞及白细胞各中医证型组中的分布有差异;外周血单核细胞与血瘀证的积分独立相关,中性粒细胞与Gensini积分独立相关。Objective To study the relationship among peripheral leucocytes, coronary artery stenosis and Chinese medicine syndromes in patients with coronary heart disease （CHD）. Methods The Chinese medicine syndromes of 189 CHD patients were differentiated into six types： the turbidity-phlegm blood-stasis type （A）, the qi-deficiency blood-stasis type （B）, the cold-congealing blood-stasis type （C）, the qi-stagnancy blood-stasis type （D）, the qi-deficiency phlegm-stasis type （E） and the turbidity-phlegm blocking laterals type （F）. Coronary angiography and peripheral leucocyte counting were performed simultaneously for determining the degree of blood-stasis by scoring （ BSS）, and the outcome of coronary angiography was evaluated depending Gensini scoring system. All data obtained were analyzed statistically. Results The highest BSS, that means the highest degree of coronary artery stenosis, was shown in patients of Chinese medicine type C, following with type A, B and D in order, the lowest level was found in the non-blood-stasis groups, namely, patients of Chinese medicine type E and F. Peripheral count of leucocytes were correlated with the BSS and Gensini score, count of mononuclear cell was individually correlated with BSS, and that of neutrophil was individually correlated with Gensini score. Conclusions BSS and distribution of peripheral leucocytes were different in CHD patients of various Chinese medicine types, count of peripheral mononuclear cell is individually correlated with BSS, and that of neutrophil is individually correlated with Gensini score.

关 键 词：冠心病 外周血白细胞 血瘀证积分 GENSINI积分 

分 类 号：R259[医药卫生—中西医结合]