冠心病伴2型糖尿病患者临床和冠脉造影分析  

The clinical and coronary angiographic analysis of patients with coronary heart disease and type 2 diabetes mellitus

作　　者：王华[1] 冯波[1] 王元元[1] 

机构地区：[1]同济大学附属东方医院内分泌科,上海200120

出　　处：《同济大学学报（医学版）》2010年第1期79-83,共5页Journal of Tongji University(Medical Science)

基　　金：国家"九七三"重点基础研究发展计划资助项目(2006CB503900)

摘　　要：目的探讨冠心病合并2型糖尿病患者的临床及冠状动脉病变特点。方法用冠状动脉造影方法分析了419例伴有2型糖尿病(161例)和不伴有糖尿病(258例)冠心病患者冠脉病变特点并将临床特点加以对照研究。结果冠心病并发2型糖尿病者空腹血糖和高血压患病率明显高于非糖尿病组(P<0.05)。两组之间血脂指标如总胆固醇、甘油三酯、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇无明显差异。冠心病伴糖尿病组的心脏射血分数较非糖尿病组明显降低。冠心病伴糖尿病组Gensini积分、范围积分和冠脉积分高于非糖尿病组,糖尿病组三支病变明显多于非糖尿病组,非糖尿病组单支病变多见。结论冠心病患者合并2型糖尿病后冠状动脉的病变复杂严重,而糖尿病对心脏功能的影响必须系统全面地进行评价。Objective To study the clinical characters and coronary artery disease features in type 2 diabetes mellitus （DM） patients with coronary heart disease （CHD）. Methods All of 419 CHD patients including 161 cases complicated type 2 DM and 258 cases without DM were performed angiographies in coronary arteries. Then the clinical characters and coronary angiographic features were analyzed and compared between two groups. Results The incidence of hypertension and the levels of fasting blood glucose（FBG） were significantly higher in the DM group than those in the non- DM group （P〈0.05）. Total cholesterol （TC） ,triglyceride （TG） ,high density lipoprotein cholesterol （HDL-C） and low density lipoprotein cholesterol （LDL-C） had no differences between two groups （P〉0.05）. There was significant decrease in ejection fraction（EF） value in DM group compared with that in non-DM group. Gensini scores and extension scores had significant increase in DM group as compared with that in non-DM group. There was significant higher incidence of single vascular lesion in non-DM group,however,more triple vascular lesions were in DM group. Conclusion Compared with non-DM patients, the DM patients have more severe and extensive coronary lesions The effect of DM on the heart function must be evaluated comprehensively and systematically.

关 键 词：冠心病 2型糖尿病 冠脉造影 

分 类 号：R587.1[医药卫生—内分泌]