长春花生物碱合成途径调控机制研究进展  

Advances in Research of Regulation and Controlling for Alkaloids Biosynthesis in Catharanthus Roseus

作　　者：伍春莲[1] 杨军[1] 陈卫英[1] 孙敏[2] 

机构地区：[1]西华师范大学生命科学学院,四川南充637002 [2]西南大学生命科学学院,重庆400715

出　　处：《药物生物技术》2010年第1期91-94,共4页Pharmaceutical Biotechnology

基　　金：西华师范大学科研启动项目(编号:06B026);四川省教育厅青年基金项目(编号:07ZB089)资助

摘　　要：长春花是一种重要的药用植物,其中含多种抗癌生物碱,然而在植物体内的含量甚微。文章对长春花生物碱合成途径中上游、中游、下游3个方面进行分阶段阐述,在每一个阶段对影响生物碱合成的物质,特别是关键酶进行了详细的综述。最后,对长春花生物碱合成途径的复杂调控性、影响因素和人工改造提出了一些设想。Catharanthus Roseus is one of the important medicinal plants that contained most anti-cancer alkaloids, but they can＇t meet the requirement of market because of the limited content in Catharanthus roseus. In this paper, the upstream, midstream and downstream of alkaloids biosynthesis in Catharanthus roseus were illustrated and the substances of affecting alkaloid biosynthesis, especially key enzyme, were summarized in detail. In conclusion, some ideas were brought forward on the complicated regulation, influencing factors and artificial reconstruction of biosynthesis pathways.

关 键 词：长春花 生物碱 合成途径 调控机制 

分 类 号：R284[医药卫生—中药学]