感染旋毛虫兔血清酶变化与虫体密度关系  

Studies on the Relationship between Five Serum Enzymes and the Larvae Density in Rabbits Infected with Trichinella Spiralis

作　　者：李立宏[1] 李宝亮[2] 陈立峰[3] 唐宏炜[4] 张进顺[4] 

机构地区：[1]河北北方学院医学检验学院临床检验教研室,河北张家口075000 [2]河北北方学院附属第一医院检验科,河北张家口075000 [3]河北北方学院基础医学院生理教研室,河北张家口075000 [4]河北北方学院医学检验学院寄生虫学教研室,河北张家口075000

出　　处：《河北北方学院学报（医学版）》2010年第1期41-43,共3页Journal of Hebei North University:Medical Edition

摘　　要：目的:探讨旋毛虫病时肌酸激酶(CK)、醛缩酶(ALD)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)和乳酸脱氢酶(LDH)与虫体密度的关系,为旋毛虫病血清酶的检测分析提供参考资料。方法:将实验用兔随机分成三组:轻度感染组、重度感染组和对照组,感染后不同时间检测血清CK、ALD、ALT、AST和LDH活性,处死后用人工消化法进行肌幼虫计数。结果:兔旋毛虫病时五种血清酶(CK、ALD、ALT、AST和LDH)均升高,五种血清酶与宿主腓肠肌虫体密度有相关性。结论:CK、ALD、ALT、AST及LDH与宿主腓肠肌虫体密度有相关性。Objective： To study the relationships between serum creatine kinase（CK）, fructosediphosphate aldolase （ALD）, alanine aminotransferase（ALT）, aspartate aminotransferase （ AST）, lactate dehydrogenase （LDH）and the larvae density in rabbits infected with Trichinella spiralis, so as to supply basic data for serum enzymes examination in trichinosis. Methods： Experimental rabbits were divided into three groups：lightlyinfected group, heavily-infected group,and control group. The sera were obtained at interval stages＇ postinfection from infected rabbits,the activities of serum CK, ALD, ALT, AST and LDH were determined. After the rabbits infected with T. spiralis were killed, the muscles larvae numbers were counted by an artifical digestion technique. Results： The level of the five serum enzymes（CK. ALD. ALT. AST and LDH）all raised. There was positive significant correlation between the levels of five serum enzymes and larvae density in the gastrocnemius muscles. Conclusion： There was significant correlation between the peaks values of five serum enzymes（CK. ALD.ALT.AST and LDH）and larvae density in the gastrocnemius muscles.

关 键 词：旋毛虫病 血清 酶类 虫体密度 兔 

分 类 号：R383.15[医药卫生—医学寄生虫学]