敦煌石室大宝胶囊对衰老大鼠脑组织单胺类神经递质的影响  

Effect of Dunhuang Shishi Dabao capsule on monoamine neurotransmitter in brain tissue of aging model rats

作　　者：程容[1] 段永强[1] 成映霞 梁玉杰 王道坤 

机构地区：[1]甘肃中医学院基础课部,甘肃兰州730000

出　　处：《中国老年学杂志》2010年第4期478-480,共3页Chinese Journal of Gerontology

基　　金：甘肃省科技攻关计划项目(2GS064-A43-020-22);兰州市科技局计划项目(06-2-87)

摘　　要：目的观察敦煌石室大宝胶囊(DHDB)对衰老模型大鼠脑组织单胺类神经递质去甲肾上腺素(NE)、多巴胺(DA)和5-羟色胺(5-HT)含量的影响。方法采用D-半乳糖建立大鼠衰老模型,测定大脑皮层内的NE、DA和5-HT含量。结果模型组大鼠脑组织内NE、DA、5-HT含量与空白组比较均有明显降低(P<0.05),应用DHDB治疗后,治疗组大鼠脑组织内NE、DA、5-HT含量均显著增高(P<0.05)。结论DHDB可提高衰老模型动物脑组织单胺类神经递质的含量,对改善大脑功能有一定的作用。Objective To explore the effect of Dunhuangdabao （DHDB） on monoamine neurotransmitter norepinephrine （NE） ,dopamine （DA） and 5-hydroxytryptamine （5-HT） levels in the brain tissue of aging model rats. Methods The subacutely aging model rats were made by injecting D-gal into abdominal cavity continually,and cerebral cortex NE,DA,and 5-HT levels were evaluated. Results The NE,DA and 5-HT levels in model group were significantly downregulated compared with those in normal group （P0.05,P0.05,P0.05）. After treated with DHDB,NE,DA and 5-HT levels were significantly upregulated （P0.05,P0.05,P0.05）. Conclusions DHDB can upregulate monoamine neurotransmitter levels in the brain tissue of aging model rats and plays an important role in improving cerebral function.

关 键 词：单胺类神经递质 衰老模型 大鼠 敦煌石室大宝胶囊 

分 类 号：R3[医药卫生—基础医学]