辛伐他汀对老年去卵巢大鼠骨量丢失的治疗作用  

Effects of simvastatin on osteopenia in aged ovariectomized rats

作　　者：刘钰瑜[1] 崔燎[1] 姚卫民[2] 许碧莲[1] 吴铁[1] 

机构地区：[1]广东医学院药理学教研室,广东湛江524023 [2]广东医学院呼吸疾病研究所,524001

出　　处：《中国骨质疏松杂志》2010年第2期128-131,92,共5页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金资助项目(30672470);广东省教育厅育苗工程项目(08-NYM-061)

摘　　要：目的观察辛伐他汀对老年去卵巢大鼠骨量丢失的治疗作用。方法10月龄SD大鼠行双侧卵巢切除术,术后2个月开始用药物治疗,用药2个月后用骨组织形态计量学方法测定大鼠第四腰椎松质骨静态、动态参数,大鼠第五腰椎体应用骨生物力学方法作椎体压缩试验。结果辛伐他汀使去卵巢大鼠骨小梁面积(%Tb.Ar)增加不明显,与去卵巢组相比,差异无统计学意义;但辛伐他汀可改善去卵巢大鼠椎骨的生物力学状况,表现在能使去卵巢大鼠的破坏载荷和破坏应力增加。结论辛伐他汀对老年去卵巢大鼠椎骨的生物力学状况有改善作用。Objective The present study was designed to investigate the preventive effects of simvastatin on osteopenia in aged ovarieetomized （OVX） rats. Methods Female, 10-month-old SD rats were ovarieetomized （OVX） and, 2 months later, were treated With simvastatin or controls for 2 months. The static and dynamic parameters in trabecular bone of the fourth lumbar vertebrae （LV4） were examined with histomorphometrieal analyses; the fifth lumbar vertebrae （LVS） were used to perform the compression test. Results Compared with the data from the sham-operated rats, the percent trabecular area,break stress and elastic modulus significantly decreased in OVX rats. Correspondingly, the bone break load decreased of post OVX was compared with those of sham-operated rats. Simvastatin increased the percent trabecular area compared with OVX rats, but it couldn＇t meet the statistical significance. Simvastatin enhanced the break load and break stress compared with OVX rats. Conclusion Simvastatin can improve biomechanics of bone in aged ovarieetomized osteopenia rats.

关 键 词：辛伐他汀 骨组织形态计量学 骨生物力学 大鼠 骨质疏松 

分 类 号：R332[医药卫生—人体生理学] R683[医药卫生—基础医学]