病理学诊断在羊水栓塞诊断中的价值  

Pathological Diagnosis in Confirming Amniotic Fluid Embolism

作　　者：黄神姣[1] 余艳红[1] 盛超[1] 吴英[1] 

机构地区：[1]南方医科大学南方医院,广东广州510515

出　　处：《实用妇产科杂志》2010年第2期133-135,I0001,共4页Journal of Practical Obstetrics and Gynecology

基　　金：广东省自然科学基金(项目编号:2003C60102)

摘　　要：目的:评价病理学诊断在羊水栓塞诊断中的价值。方法:健康孕晚期山羊12只,根据其股静脉中注入不同羊水性质随机分成3组:原羊水组、过滤羊水组、胎粪污染羊水组,每组4只。在羊水注入3小时后取心脏血和股静脉血查找羊水成分,同时将动物处死,取肺组织行病理学检查。结果:12只动物的中心血和外周血均找到羊水成分,肺组织均可见不同程度的肺水肿及炎性反应,原羊水组1只(25.0%)、胎粪组4只(100%)动物肺组织中找到了羊水成分,过滤羊水组无一例见羊水成分。结论:依靠病理学诊断羊水栓塞可能是不可靠的。Objective.To evaluate the value of pathological diagnosis in confirming amniotic fluid embolism （AFE）. Methods.Twelve healthy pregnant goats （Capra hircus） in the last pregnancy were randomly divided into three groups according to the different characters of amniotic fluid by femoral vein injection （ n =4 for each group）： raw amniotic fluid group（ AF group）, filtered amniotic fluid group（ FAF group） and meconiumstain amniotic fluid group （ MAF group）. Three hours after injection, centre and peripheral blood were extracted to find the amniotic fluid component, then all the animals were sacrified and lung was taken for pathological examination. Results.The centre and peripheral blood specimens from twelve animals were demonstrated amniotic fluid component. In HE stain histological examination of pulmonary samples revealed the presence of pulmonary edema and inflammation. Amniotic fluid component was found in 1 animal （25%） in AF group, in 4 animals in MAF group（100%） and none in FAF group. Conclusions. Pathological diagnosis in confirming amniotic fluid embolism may be unreliable.

关 键 词：羊水栓塞 羊水成分 诊断 病理学 

分 类 号：R714.468[医药卫生—妇产科学]