乌司他丁对胸外科手术患者围手术期炎症介质的影响  

Effects of ulinastatin on perioperative inflammatory media in patients ungoing thoracic operations

作　　者：郑翠英[1] 张连祥[1] 蔡忠[1] 艾静[1] 

机构地区：[1]天津市胸科医院检验科,300051

出　　处：《江苏医药》2010年第3期265-267,共3页Jiangsu Medical Journal

摘　　要：目的探讨乌司他丁对胸外科手术患者围手术期炎症介质的影响。方法40例胸外科手术患者随机分为乌司他丁用药组和对照组,每组20例,应用酶联免疫法检测血清白细胞介素6(IL-6)、白细胞介素8(IL-8)、肿瘤坏死因子α(TNF-α)在术前、术后1、4、24、72 h的动态变化。结果IL-6I、L-8术后1 h均显著升高,4、24、72 h逐渐降低,乌司他丁用药组升高幅度明显低于对照组(P<0.05)。结论乌司他丁可降低术后IL-6I、L-8、TNF-α的水平,对减轻术后炎症反应有一定作用。Objective To investigate the effects of ulinastatin on perioperative inflammatory media in patients undergoing thoracic operations. Methods Fourty patients undergoing thoracic operations were randomly divided into ulinastatin group and control group with 20 cases each. Blood samples were taken before operation, at 1,4;24, 72 h after surgery for the measurements of tumor necrosis factor-α（TNF-α）,interleukin（IL）-6 and IL-8 by enzyme immunoassay. Results The levels of IL-6 and IL-8 significantly increased at 1 h after operation and reduced at 4,24 and 72 h gradually in two groups. The magnitude of increase of IL-6 and IL-8 was less in ulinastatin group than that in control group （P〈0. 05）. Conclusion Ulinastatin decreases the levels of IL-6, IL-8 and TNF-α during thoracic surgery and may be helpful in reducing inflammatory response.

关 键 词：乌司他丁 白细胞介素6 自细胞介素8 肿瘤坏死因子Α 

分 类 号：R453[医药卫生—治疗学]