支气管肺泡灌洗液的结核分枝杆菌快速培养对疑似肺结核的诊断价值  

Diagnostic Value of Rapid Culture for Mycobacterium Tuberculosis in Bronchoalveolar Lavage Fluid in Atypical Pulmonary Tuberculosis

作　　者：滕忠强[1] 张新[2] 胡必杰[2] 周昭彦[2] 周春妹[2] 洪群英[2] 胡洁[2] 李春[2] 殷霞[2] 

机构地区：[1]福建卫生职业技术学院附属福建省级机关医院呼吸内科,福州350003 [2]复旦大学附属中山医院呼吸内科,上海200032

出　　处：《中国临床医学》2010年第1期35-36,共2页Chinese Journal of Clinical Medicine

摘　　要：目的:评价支气管肺泡灌洗液的结核分枝杆菌快速培养在疑似肺结核患者中的诊断价值。方法:选不典型肺结核患者153例,行电子支气管镜检查。刷检涂片作抗酸染色镜检;支气管肺泡灌洗,支气管肺泡灌洗液(BALF)作分枝杆菌生长指示管(MGIT)快速培养福建卫生职业技术学院附属分枝杆菌。结果:BALF快速培养结核分枝杆菌、经支气管镜刷检涂片镜检分枝杆菌的的灵敏度、特异度分别为94.12%(32/34)、95.80%(114/119)和52.94%(18/34)、96.64%(115/119)。前者灵敏度高于后者,经统计学检验显示有显著差异(P<0.01)。结论:对于临床不典型的肺结核,经气管镜行支气管肺泡灌洗液的结核分枝杆菌快速培养,灵敏度高,快速及时,具有较高的诊断价值。分枝杆菌培养及鉴定有助于提高临床肺结核的确诊率。Objective：To evaluate the diagnostic value of rapid culture for mycobacterium tuberculosisin bronchoalveolar lavage fluid （BALF） for atypical pulmonary tuberculosis. Methods：There were 153 cases underwent electron bronchoscopy examination. All samples of bronchial brushing were tested for myeobacterium by microscope examination using acid fast staining and bronchoalveolar lavage fluid （BALF） using by mycobacteria growth indicate tube （MGIT） rapid culture methods. Results： The sensitivity, specificity of rapid culture for mycobacterium tuberculosisin BALF were 94. 12% （32/34） and 95.80% （ 114/l 19）, respectively ; while for bronchial brushing were 52.94%（18/34） and 96.64% （ 115/119）, respectively. The sensitivity of rapid culture for mycobacterium tuberculosisin BALF was significantly higher than bronchial brushing（P〈0.01 ）. Conclusions： Rapid culture for mycobacterium tuberculosisin BALF is of significant clinical value for the early quick diagnosis of atypical pulmonary tuberculosis.

关 键 词：支气管肺泡灌洗液 培养 肺结核 诊断 

分 类 号：R521[医药卫生—内科学]