代谢综合征患者血清脂联素及肿瘤坏死因子-α与内皮损害的关系  

Association of serum adiponectin and tumor necrosis factor alpha with endothelial damages in metabolic syndrome patients.

作　　者：武海亮[1] 刘雅娟[1] 杨锐英[1] 

机构地区：[1]宁夏医科大学附属医院心脏中心干部病房,银川750004

出　　处：《中国综合临床》2010年第3期239-242,共4页Clinical Medicine of China

基　　金：宁夏自然科学基金项目（Nz0574）

摘　　要：目的研究代谢综合征（MS）患者血清脂联素及肿瘤坏死因子-α（TNF-α）与内皮损害的关系。方法选取满足MS诊断条件的患者为病例组（105例），并根据血浆假性血友病因子水平将病例组分为MS内皮功能正常组（57例）和MS内皮功能异常组（48例），无MS特征者为正常对照组（37例）。酶联免疫吸附试验法测定所有个体的血清脂联素，放射免疫法测定TNF-α。结果正常对照组脂联素（10．5±3．2）mg／L显著高于MS内皮功能正常组（7．9±2．2）mg／L和MS内皮功能异常组（6．5±2．5）mg／L，差异有统计学意义（P均〈0．05），TNF-α（0．17±0．04）μg／L显著低于MS内皮功能正常组（0．19±0．05）μg／L和MS内皮功能异常组（0．23±0．06）μg/L，差异有统计学意义（P均〈0．05）；脂联素与TNF-α呈负相关（r=-0．555，P〈0．01）；Logistic回归分析显示：TNF—α为内皮损害的危险因素（OR=20．649，P=0．035），脂联素为保护因素（OR=0．340，P=0．006）。结论脂联素水平降低和TNF-α水平升高可能与代谢综合征患者内皮功能损害相关。Objective To investigate the association of serum adiponectin and tumor necrosis factor alpha （TNF-ot） with endothelial damages in metabolic syndrome （MS） patients. Methods One-hundred and five patients diagnosed as MS were recruited as cases and 37 subjects without characteristics of MS were recruited as controls. The cases were divided into two groups according to the level of serum von Willebrand factor （vWF） ：normal endothelial functional MS group （57 patients） and abnormal endothelial functional MS group （48 patients）. Serum adiponectin concentration was measured by enzyme-linked immunosorbent assay （ELISA）. Serum TNF-α concentration was measured by radioimmunoassay （RIA）. Results The concentration of serum adiponectin in normal subjects （ 10.5 mg/L [ SD ： 3.2 ] ） was significantly higher than both that of normal endothelial functional MS group （7.9 mg/L [ SD ： 2.2 ] ） and abnormal endothelial functional MS group （6.5 μg/L [ SD ：2.5 ] ） （ P 〈 0.05 ）. The concentration of serum TNF-α in normal subjects （0.17 μg/L [ SD ：0.04 ] ） were significantly lower than that of normal en- dothelial functional MS group （0. 19 μg/L [ SD：0.05 ] ） and abnormal endothelial functional MS group （0.23 ng/ml [ SD ： 0.06 ] ） （ P 〈 0. 05 ）. The level of serum adiponectin were negatively correlated with TNF-α （ r = - 0. 555,P 〈 0.01 ）. Logistic regression analysis results showed that high level of TNF-α was a risk factor of endo- thelial damages （ OR = 20.649, P = 0. 035 ）, whereas high level of serum adiponectin protected against endothelial damages （ OR = 0.340,P = 0.006）. Conclusions Low level of serum adiponectin and high level of serum TNF-α may correlate with endothelial damages in MS patients.

关 键 词：代谢综合征 内皮功能 脂联素 肿瘤坏死因子-Α 

分 类 号：R589[医药卫生—内分泌]