果糖二磷酸钠联合α-硫辛酸治疗糖尿病周围神经病变临床效果观察  

Effect of fructose sodium diphosphate and alpha-lipoic acid on diabetic peripheral neuropathy.

作　　者：陈玉凤[1] 沈育芬[1] 张会娟[1] 

机构地区：[1]郑州大学第一附属医院内分泌科,450052

出　　处：《中国综合临床》2010年第3期292-294,共3页Clinical Medicine of China

摘　　要：目的观察果糖二磷酸钠与α-硫辛酸联合治疗糖尿病周围神经病变的临床疗效。方法66例糖尿病患者随机分为治疗组34例（其中3例因不能耐受退出该研究），对照组32例。在控制血糖的基础上，治疗组给予果糖二磷酸钠10g、α-硫辛酸0．45g，静脉滴注。对照组给予α-硫辛酸0．45g，静脉滴注。2组均为1次／d，疗程2周。观察治疗后症状改善情况，并测定治疗前后正中神经和腓总神经的运动传导速度和感觉传导速度。结果治疗2周后，治疗组总有效率93．55％（28／31），对照组总有效率68．75％（22／32），治疗组临床疗效较对照组明显改善（P〈0．05）。运动神经传导速度治疗组[正中神经为（47．7±3．8）m／s与（42．5±2．5）m／s，腓总神经为（41．6±3．3）m／s与（36．0±2．8）m／s]与对照组[正中神经为（43．4±2．0）m／s与（41．9±16．0）m／s、腓总神经为（39．6±3．3）m／s与（36．2±1．9）m／s]和感觉神经传导速度[正中神经为（40．3±1．8）m／s与（35．2±2．3）m／s、腓总神经为（34．1±2．3）m／s与（28．8±2．5）m／s]、对照组[正中神经为（37．7±1．7）m／s与（34．8±3．1）m／s、腓总神经为（30．8±2．6）m／s与（27．8±2．4）m／s]均较治疗前提高（P均〈0．05），但治疗组提高更明显（P〈0．01）。结论果糖二磷酸钠与d-硫辛酸联合治疗糖尿病周围神经病变，疗效较好。Objective To assess the effect of fructose sodium diphosphate and alpha-lipoic acid on diabetic peripheral neuropathy. Methods Sixty-six patients with diabetic peripheral neuropathy were randomly divided into two groups, additional to the regular treatment to control blood glucose, 34 patients in the treatment grouptreated with fructse sodium diphosphate 10 g and alpha-lipoic acid 0.45 g daily through intravenous drip for two weeks （3 patients dropped out due to un-tolerance）, 32 patients in the control group treated with alpha-lipoic acid 0.45 g daily through intravenous drip for two weeks. All patients were examined on the improvement of symptoms, motor and sensory nerve conduction velocity of the median nerve and nervus peroneus communis before and after the treatment. Results After treatment for two weeks, the overall effect rate in the treatment group was 93.55% （28/31）, which was significantly higher than that in the control group （68.75%, 22/32） （P 〈 0.05 ）. In the treatment group, the motor nerve conduction velocity for the median nerve and nervus peroneus communis was 47.7 （ SD ：3.8） m/s and 41.6 （ SD ： 3.3） m/s after treatment, which was significantly higher than that before treatment （42.5 [ SD ：2.5 ] and 36.0[ SD ：2.8 ] m/s, respectively） （P 〈 0.05 ）. In the control group, the motor nerve conduction velocity for the median nerve and nervus peroneus communis was 43.4 （ SD ：2. 0） m/s and 39.6 （ SD： 3.3 ） m/s after treatment,which was significantly higher than that before treatment （41.9 [ SD16.0 ] and 36.2 [ SD ： 1.9 ] m/s, respectively） （P 〈 O. 05）. In the treatment group,the sensory nerve conduction velocity for the median nerve and nervus peroneus communis was 40.3 （ SD ： 1.8 ） m/s and 34. 1 （ SD ： 2.3 ） m/s after treatment, which was significantly higher than that before treatment （35.2 [ SD： 2.3 ] and 28.8 [ SD ： 2.5 ] m/s, respectively） （P 〈 0.05 ）. In the control group, the sensory nerve conduction veloc

关 键 词：糖尿病周围神经病变 果糖二磷酸钠 仪.硫辛酸 

分 类 号：R587.2[医药卫生—内分泌] R541.405[医药卫生—内科学]