肥胖者吸烟对动脉僵硬度与氧化应激的影响  

Obesity and cigarette smoking impaired arterial stiffness with oxidative stress

作　　者：欧阳驰[1] 陈晓岚[1] 莫艳秀[1] 汤银娟[1] 李石旺[1] 刘科峰[1] 

机构地区：[1]湘南学院基础医学课部,湖南省郴州市423000

出　　处：《中国医药》2010年第3期199-200,共2页China Medicine

基　　金：基金项目：湖南省教育厅科研基金资助项目（09C911）

摘　　要：目的观察肥胖者吸烟对动脉僵硬度及氧化应激的影响。方法选取大学在校男生85人，按照BMI或腰围大小分为2组，对照组41人，实验组44人，实验组进行吸烟干预25d，对照组无任何干预，测定对照组及实验组吸烟前、后每位受试者动脉僵硬度、血浆谷胱甘肽、丙二醛、尿酸含量并进行对比。结果实验组吸烟前与对照组比较，动脉僵硬度（1．78±0．26VS1．97±0．38，P〈0．05）及血浆丙二醛[（3．88±1．13）μmol／LVS（4．32±1．56）μmol／L，P〈0．05]、尿酸含量[（295±43）μmol／LVS（361±57）μmol／L，P〈0．05]显著增高；实验组吸烟后与对照组及实验组吸烟前比较，动脉顺应性显著下降[（1．54±0．32）ml／mmHgVS（1．97±0．38）ml／mmHg，P〈0．01；（1．54±0．32）ml／mmHgVS（1．78±0．26）ml／mmHg，P〈0．05]，与对照组比较，实验组吸烟前后丙二醛尿酸含量则显著上升[丙二醛：（4．32±1．56）vs（3．88±1．13），（4．77±1．07）vs（3．88±1．13）；尿酸：（361±57）VS（295±43），（472±39）μmol／L vs（295±43）μmol／L，P〈0．01或P〈0．05]。结论氧化应激反应产物丙二醛、尿酸含量的增高，说明机体氧化．抗氧化机制失衡有助于动脉僵硬度和动脉顺应性发生改变，增加心血管疾病的患病风险，而肥胖者吸烟更具有患病的高危性。Objective To investigate the effect of obesity and cigarette smoking on arterial stiffness with oxidative stress. Methods Eighty five healthy male students were divided into two groups according to BMI or waist circumference. Group A was control group（ n = 41 ） , group B was obese group（ n = 44 ） which was given cigarette smoking for 25 days. Then, arterial stiffness, plasma malonaldehyde（MDA） and uric acid（UA） levels of each sub- ject in group A, pre-and post-cigarette smoking of group B were analyzed. Results The arterial stiffness （ 1.78 ± 0.26 vs 1.97 ±0.38, P 〈0.05）, plasma MDA（3, 88 ± 1.13 vs d. 32 ± 1.56, P 〈0.05） and UA（295 ±43 vs 361 ± 57, P 〈 0.05） levels were significance higher in pre-cigarette smoking of group B compared with group A. The arterial compliance was significance lower（ 1.97 ± 0. 38 vs 1.54 ± 0.32, P 〈 0.01 ） and the plasma UA level（ 295 ± 43 vs 472 ± 39, P 〈 0.01 ） was significance higher in post-cigarette smoking of group B than that in other groups. Conclusions The plasma MDA and UA levels increased, which were product of oxidative stress. These indicated that the disorder of oxidation-antioxidation impaired arterial stiffness and arterial compliance, also exacerbated the morbidity and mortality of cardiovascular disease in obesity and cigarette smoking.

关 键 词：肥胖 吸烟 动脉僵硬度 氧化应激 

分 类 号：R589.2[医药卫生—内分泌]