重组人表皮生长因子联合磺胺嘧啶银霜治疗糖尿病足溃疡的疗效观察  

The effect of recombinant human epidermal growth factor combining silvadene cream on diabetic foot ulcer

作　　者：徐礼五[1] 齐晓玲[1] 袁玲[1] 王郭伟[1] 段成[1] 余洋[1] 李晓蕾[1] 王江宁[1] 刘智[1] 

机构地区：[1]淮南市第一人民医院内分泌肾病科,安徽省淮南232007

出　　处：《中国基层医药》2010年第3期313-314,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察重组人表皮生长因子与磺胺嘧啶银霜局部联合应用治疗糖尿病足溃疡的疗效。方法18例2型糖尿病足溃疡合并感染患者，按Wagner分级，在常规治疗基础上，局部采用重组人表皮生长因子与磺胺嘧啶银霜联合应用，观察溃疡愈合情况。结果18例患者中有2例因经济等原因自动出院，有12例住院期间足溃疡愈合，治愈率达75％，愈合时间10～47d，另有4例出院时足溃疡愈合面积超过原溃疡面的1／2，出院后仍然采用重组人表皮生长因子及磺胺嘧啶银霜局部联合应用，有2例随访1个月愈合良好。结论糖尿病足溃疡病变程度在Wagner4级及以下的病例通过使用包括重组人表皮生长因子及磺胺嘧啶银霜局部应用在内的综合治疗，可使一部分患者避免外科手术甚至截肢之苦。Objective To observe the effect of recombinant human epidermal growth factor combining silvadene cream on diabetic foot ulcer. Methods Total 18 T2DM patients with diabetic foot ulcer concurrent infection defined by the Wagner Classification were observed, everyone were treated base on the conventional therapy, except for the use of recombinant human epidermal growth factor combining silvadene cream on the ulcer. Results 2 patients were discharged voluntarily because of economic reason. 12 patients had complete healing between 10 and 47 days, the healing rate reached 75%. Another 4 patients were recovered surpassing half of the original ulcer during the hospital stay, and they continue the use of recombinant human epidermal growth factor combining silvadene cream post-discharge,2 patients healing well follow up one month visit. Conclusion Diabetic foot ulcer less Grade 4 defined by the wagner classification can be treated by combined therapy including the use of recombinant human epidermal growth factor combining silvadene cream on the wound,which can avoid moiety patients suffering surgery even amputation.

关 键 词：糖尿病足 重组人表皮生长因子 磺胺嘧啶银霜 

分 类 号：R587[医药卫生—内分泌]