曲尼司特滴眼液的处方研究  

Formulation Study of Eye Drops of Tranilast

作　　者：缪玉山[1] 孙彦甫[1] 陈国明[1] 徐仁南[1] 

机构地区：[1]东南大学附属中大医院,南京210009

出　　处：《中国现代应用药学》2010年第2期132-134,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的增加曲尼司特的溶解度,筛选出合格的曲尼司特滴眼液处方。方法以稳定性为指标,拟采用包合、增溶或助溶技术制备曲尼司特滴眼液。结果以葡甲胺作助溶剂制备的曲尼司特滴眼液在光照(4 000 lx)、低温(4℃)、高温(60℃)10 d及室温留样考察12个月,物理及化学性质稳定。结论研制的曲尼司特滴眼液达到设计要求。OBJECTIVE To screen good formulations of tranilast eye drops by solubilizing.METHODS Tranilast eye drops were prepared by inclusion compound or solubilizers method according to stability.RESULTS The physico-chemical stability was good after storing 10 d under illumination（4 000 lx）,4 ℃,60 ℃ and 12 months under room temperature.CONCLUSION Tranilast eye drops could be made successfully.

关 键 词：曲尼司特 滴眼剂 稳定性 溶解度 处方研究 

分 类 号：R944.1[医药卫生—药剂学]