可降解手术缝合线复合多孔玻璃基生物骨水泥的制备和性能研究  

The study on preparation and properties of porous glass based bone-cement compounded with catgut thread

作　　者：王慧宇[1] 周萘[1] 姚维芳[2] 黄文旵[1] 

机构地区：[1]同济大学材料科学与工程学院,上海200092 [2]上海新华医院骨科,上海200092

出　　处：《功能材料》2010年第2期185-188,192,共5页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(50572072)

摘　　要：以可降解手术缝合线作为造孔剂添加在多孔骨水泥中,生成连通孔道。与骨水泥中甘露醇降解形成的立方体小孔共同构成树枝状孔隙结构,进而更好地诱导骨组织的长入。实验采用EDTA法测定了钙离子离析浓度,利用体视显微镜和SEM对连通孔道内表面的显微结构进行了观察和分析。试验结果表明,缝合线的降解有助于羟基磷灰石的生成;1.5倍SBF环境液中,骨水泥中缝合线在初期降解不明显,15d时达到降解高峰;30d后骨水泥内部生成树枝状体系孔隙结构。The dentritic channel conformation which is created by mannitol and catgut thread compounded with bone cement could induce deeply growth of new bone cells.In this study,the concentration of calcium ions is determined by method of EDTA.The surface and structure of long channel is investigated by three-dimensional microscopic analysis and SEM.The results show that the dissolution of catgut thread could promote growth of HAP.In 1.5 time concentration of SBF,the dissolution phenomenon of thread is not distinct in the prime stage,and at 15d,the dissolution reaches at peak phase.After 30d,the dentritic channel conformation is created in the matrix of bone cement.

关 键 词：玻璃基骨水泥 羟基磷灰石(HAP) 可降解手术缝合线 树枝状 生物相容性 

分 类 号：TQ171.74[化学工程—玻璃工业]