原位水化法制备羟基磷灰石/壳聚糖复合支架材料  

Preparation of hydroxyapatite/chitosan composite scaffolds via in-situ hydration

作　　者：李红[1] 朱敏鹰[1] 周长忍[1] 

机构地区：[1]暨南大学理工学院材料科学与工程系,广东广州510630

出　　处：《功能材料》2010年第2期256-259,共4页Journal of Functional Materials

基　　金：国家高技术研究发展计划(863计划)资助项目(2007AA091603);国家自然科学基金资助项目(30870612)

摘　　要：以含Ca2+和PO34-的溶液为无机相,壳聚糖(chitosan,CS)溶液为高分子相,采用原位水化法制备羟基磷灰石(hydroxyapatite,HAP)/CS复合多孔支架材料。XRD和IR的表征和分析表明水化24h后,复合支架中的钙磷盐从磷酸氢钙(dicalciumphos phate dehydrate,DCPD)转化为HAP。SEM和EDS显示15μm左右的棒状HAP颗粒均匀地分散在多孔支架的孔壁上,压缩强度的测试结果表明这种结构显著提高复合支架的力学性能。Hydroxyapatite（HAP）/chitosan（CS） composite is a biocompatible and bioactive biocomposite.In order to enhance the properties of the composite,a novel homogenous HAP/CS composite scaffold was developed via lyophilization and in situ hydration.The morphologies,components,mechanical strength,bioactivity and biocompatibility of the composite scaffolds were investigated.The HAP particles with relatively homogenous distribution in the pore-wall surface of the scaffold were obtained while the scaffold remained sponge structure after hydration treatment.X-ray diffraction（XRD） and Fourier-Transformed Infrared spectroscopy（FTIR） confirmed the phase purity of the formed HAP crystals.The compressive strength of the scaffold showed much higher than those of the scaffold blended and the CS-only scaffold.The results suggest that the homogenous composite scaffolds with better strength can be prepared via the in situ hydration process,which may serve as a good scaffold for bone tissue engineering.

关 键 词：壳聚糖 羟基磷灰石 支架 原位水化 

分 类 号：TB39[一般工业技术—材料科学与工程]