基于功效和物质基础的鸦胆子毒性研究进展  

Research Development on Toxicity of Fructus Bruceae Based on Efficacy and Material Basis

作　　者：孙蓉[1] 杨倩[2] 

机构地区：[1]山东省中医药研究院,山东济南250014 [2]山东中医药大学,山东济南250355

出　　处：《中国药物警戒》2010年第3期159-161,共3页Chinese Journal of Pharmacovigilance

基　　金：国家973计划中医基础理论专项;确有疗效的有毒中药科学应用关键问题的基础研究;项目编号:2009CB522800;有毒中药的毒性与功效;证候关系的基础研究;课题编号:2009CB522802

摘　　要：目的为进行鸦胆子功效和物质基础与毒性的相关性研究提供文献依据和研究思路。方法对鸦胆子历代文献古籍及近十几年来国内相关文献进行整理、分析和归纳。结果历代文献古籍对鸦胆子功效的认识基本一致,对其毒性的认知却不尽相同。鸦胆子在临床使用中可产生多种不良反应,水溶性苦木内酯类化合物是其主要毒性物质基础。结论目前鸦胆子针对功效、物质基础和毒性的研究都是孤立的,彼此之间缺少关联性。应该在功效表达和物质基础分离过程中进行毒性研究,并对其毒性物质基础进行合理控制,为临床安全用药提供依据。Objective Provide literature basis and idea for the research of relevance between efficacy, material basis and toxicity. Methods Ancient books ,literature in past dynasties and references in the last decades at home about Fructus Bruceae were collected, analyzed and summarized. Results The efficacy of Fructus Bruceae that was recorded in ancient books and modem references are similar, but it isn＇t that about toxicity. Many adverse reaction were observed in clinical application. Quassinoide Compounds are the material basis of its toxicity. Conclusion The research about efficacy,material basis and toxicity of Fructus Bruceae is isolated, there is a short of relevance.The toxicity of Fructus Bruceae should be researched in the process of efficacy-expression and material basis-separation. Material basis of toxicity should be controled reasonably and basement would be provided for safe medication in clinical.

关 键 词：鸦胆子 功效 物质基础 毒性 

分 类 号：R961.1[医药卫生—药理学] R994.13[医药卫生—药学]