糖尿病肾病患者血清胱抑素C与肌酐检测分析  

Analysis on Detection of Serum Cystatin C and Creatinine of Patients with Diabetic Nephropathy

作　　者：徐晓宏[1] 王立新[1] 王淑敏[1] 

机构地区：[1]黑龙江省齐齐哈尔医学院第三附属医院,161002

出　　处：《中国误诊学杂志》2010年第7期1525-1526,共2页Chinese Journal of Misdiagnostics

摘　　要：目的:探讨血清胱抑素C(CysC)对于诊断糖尿病肾病(DN)的应用价值。方法:对67例DN患者和65例正常对照者的血清CysC和肌酐(Cr)含量进行了测定比较。结果:DN组血清CysC和Cr含量分别为(1.48±0.83)mg/L和(120.8±29.1)μmol/L;正常对照组血清CysC和Cr含量分别为(0.71±0.18)mg/L和(89.3±19.5)μmol/L。经统计学处理,DN组血清CysC和Cr含量均显著高于正常对照组(P<0.05)。其中,18例Cr正常的DN患者的血清CysC却明显升高。经直线相关回归分析,血清CysC与Cr呈正相关,差异有统计学意义(r=0.538,P<0.05)。结论:DN患者的血清CysC含量明显升高,检测血清CysC有助于肾小球滤过功能的评估,CysC是反映DN患者肾损害的良好指标。Objective：To explore the value of cystatin C in diagnosis of diabetic nephropathy（DN）. Methods： To detect and compare the content of serum cystatin C and creatinine of 67 patients with DN and 65 normal controls. Results：The content of serum cystatin C and creatinine was （1.48± 0.83） mg/L, （120.8± 29.1） μmol/L respectively in DN group,and （0.71± 0.18） rag/L, （89.3± 19.5） μmol/L respectively in control group. The content of serum cystatin C and creatinine was significant higher in DN group than in control group（ P〈0.05 ） after statistics processing. By linear correlation and regression analysis,there was a positive correlation between cystatin C and creatinine, and the difference had a statistical significance（ r= 0. 538, P〈0.05 ）. Conclusions： The content of serum cystatin C shows a significant increases in patients with DN. The detection of serum cystatin C helps to evaluate the glomerular filtration function of patients with DN. Cystatin C is a valuable indices in evaluating the renal damage of patients with DN.

关 键 词：糖尿病肾病/血液 西司他汀类/血液 肌酸酐/血液 

分 类 号：R587.240.46[医药卫生—内分泌]