毛冬青中IlexgeninA和IlexsaponinA1的分离和NMR归属  

Isolation and NMR Assignment for Ilexgenin A and Ilexsaponin A1 from llex pubescens

作　　者：杨金燕[1] 张翠仙[1] 赵钟祥[1] 林朝展[1] 曾陇梅[2] 祝晨蔯[1] 

机构地区：[1]广州中医药大学中药学院,广州510006 [2]中山大学化学与化工学院,广州510275

出　　处：《天然产物研究与开发》2009年第B05期13-16,共4页Natural Product Research and Development

基　　金：基金项目：广东省中医药管理局基金（No.2007336）;广州中医药大学创新基金（No.2007C016）

摘　　要：从岭南地区习用药毛冬青Ilex pubescens Hook．Et．Am．根的乙酸乙酯提取物中分离得到2个化合物，经理化鉴定及波谱技术分析，并结合文献对照，鉴定为乌苏烷型三萜——毛冬青皂苷元A（ilexgenin A，1）和乌苏烷型三萜皂苷——毛冬青皂苷A1（ilexsaponin A1，2）。首次利用2DNMR（^1H-^1H COSY，HMBC和HMQC）技术对此两个化合物的^1H和^13CNMR数据进行了全归属。Two known compounds ilexgenin A （1） and ilexsaponin A1 （2）, were isolated from the root of llex pubescens, which is a traditional Chinese medicine used for the treatment of cardiovascular diseases. These two compounds were elucidated by chemical method,physical method and spectroscopic analysis methods. The signals of ^1H and ^13C NMR spectra of compounds 1 and 2 were recorded and completely assigned by 2D NMR experiments,including ^1H-^1H COSY, HM-BC and HMQC.

关 键 词：毛冬青 毛冬青皂苷元A 毛冬青皂苷A1 2D NMR NMR全归属 

分 类 号：Q946.83[生物学—植物学] R284.2[医药卫生—中药学]