PLA/CoFe_2O_4载药微球的制备、表征及释药性能  

Preparation,characterization and drug release propertity for PLA/ CoFe_2O_4 drug-loaded microsphere

作　　者：甄卫军[1] 袁龙飞[1] 李先进[1] 刘月娥[1] 庞桂林[1] 

机构地区：[1]新疆大学化学化工学院,乌鲁木齐830046

出　　处：《中国抗生素杂志》2010年第2期123-127,共5页Chinese Journal of Antibiotics

基　　金：2004年新疆大学青年启动基金项目(QN040113);2005年度新疆维吾尔自治区高校科研计划(课题编号:XJEDU2005E01)

摘　　要：采用乳化-溶剂挥发法制备了聚乳酸(polylactic acid,PLA)载硫酸庆大霉素复合微球。通过正交设计实验优选PLA载药微球的最佳实验条件。在此基础上利用微乳法制备的铁酸钴(CoFe2O4)制备了PLA/CoFe2O4载硫酸庆大霉素复合微球。通过透射电子显微镜(TEM)、X-射线衍射(XRD)、振动样品磁强计(VSM)对铁酸钴进行微观结构表征和性能分析。采用傅立叶变换红外光谱(FT-IR),扫描电子显微镜(SEM)、生物数码显微镜对聚乳酸载药微球和PLA/CoFe2O4载药微球进行了微观结构的表征和分析。结果表明两种载药微球呈规则球形,表面光滑,分布较均匀,平均粒径约为20μm。通过体外模拟释药试验考查了PLA载药微球和PLA/CoFe2O4载药微球的释药性能。结果表明聚乳酸作为药物载体具有明显的药缓控释作用,PLA/CoFeO载药微球药物释放持续的时间最长。Polylactic acid microspheres containing gentamycin sulfate were prepared by emulsification-solvent evaporation method. The optimum experimental conditions of PLA drug-loaded microspheres were screened by orthogonal experiment. Magnetic cobalt ferrite （CoFe2O4） was prepared by water-in-oil microemulsion processing and characterized by TEM,XRD, VSM. The microstructure of PLA drug-loaded microspheres and PLA/CoFe2O4 drug-loaded microspheres was characterized and analyzed by FT-IR, SEM and digital bio-microscope. It was shown that two kinds of drug-loaded microspheres were of regular sphere and smoothly surface. Their distribution were even and the average diameter was 20μm. The drug release of two kinds of drug-loaded microspheres was studied by invitro release method. It was shown that there was clear controlled release property for PLA and PLA/CoFe2O4 drugloaded microspheres had the longest release time.

关 键 词：聚乳酸 铁酸钴 载药微球 释药性能 

分 类 号：TB383[一般工业技术—材料科学与工程]